RELB

RELB proto-oncogene, NF-kB subunit

Summary

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and protein kinase binding activity. Involved in lymphocyte differentiation and negative regulation of interferon-beta production. Located in several cellular components, including centrosome; chromatin; and nucleoplasm. Part of nucleus and transcription repressor complex. Implicated in breast cancer and immunodeficiency 53. Biomarker of breast cancer and transitional cell carcinoma. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants347 total

rsidPosition (GRCh37)AllelesClassClinVar
rs725165519:45,502,808C/Tupstream gene variant—
rs212237093719:45,504,838A/G—uncertain significance
rs141386226819:45,504,851G/A—uncertain significance
rs117529497319:45,504,858C/T—likely benign
rs212237106619:45,504,863G/A—uncertain significance
rs105408292019:45,504,875C/T—uncertain significance
rs89281430019:45,504,877A/C—uncertain significance
rs251362756619:45,504,883C/T—uncertain significance
rs160005753519:45,504,884G/C—uncertain significance
rs117757596719:45,504,885G/C—likely benign
rs121779522119:45,504,892C/G—uncertain significance
rs126591909819:45,504,893C/G—uncertain significance
rs55859393319:45,504,894G/C—likely benign
rs74701096219:45,504,914C/T—uncertain significance
rs120610649619:45,504,917C/G—uncertain significance
rs251362763319:45,504,920C/T—uncertain significance
rs95663161319:45,504,924G/A—likely benign
rs76841468519:45,504,926C/G—uncertain significance
rs142977400719:45,504,942A/C—uncertain significance
rs100268262719:45,504,943G/A—uncertain significance
rs57626976719:45,505,227C/T——
rs75493743419:45,506,207G/T—uncertain significance
rs19121293619:45,506,208G/A—benign
rs137729894019:45,506,210C/T—uncertain significance
rs74798614919:45,506,211C/T—likely benign
rs76926251219:45,506,215G/C—uncertain significance
rs197123239419:45,506,217C/T—likely benign
rs95086239319:45,506,222C/T—uncertain significance
rs120529643419:45,506,231C/T—uncertain significance
rs77767676019:45,506,235C/G—likely benign
rs37516707219:45,506,238C/T—likely benign
rs77403095819:45,506,240T/C—uncertain significance
rs37098966619:45,506,244C/T—likely benign
rs18228610419:45,506,247G/A—likely benign
rs251362928819:45,506,257G/A—uncertain significance
rs77689389919:45,506,259G/A—uncertain significance
rs37447124219:45,506,264C/G—likely benign
rs251362930219:45,506,269A/G—likely benign
rs13939597019:45,506,270C/T—likely benign
rs212237745719:45,506,271A/C—likely benign
rs725146019:45,506,772T/G——
rs3525592119:45,507,542G/Aintron variant—
rs14091227319:45,507,696G/Aintron variant—
rs14888412119:45,510,412C/Tintron variant—
rs53143876619:45,511,321G/A——
rs19239402619:45,511,423G/Aintron variant—
rs135612614619:45,513,057C/T—likely benign
rs37247010619:45,513,059C/T—likely benign
rs55168871219:45,515,175G/A—likely benign
rs197136357619:45,515,181T/C—likely benign
rs74946303819:45,515,187C/T—likely benign
rs77107335619:45,515,204C/T—likely benign
rs137972295319:45,515,222C/T—likely benign
rs77225522119:45,515,231C/G—likely benign
rs212241381219:45,515,237C/T—likely benign
rs251363803919:45,515,243A/G—likely benign
rs251363804419:45,515,244C/T—uncertain significance
rs77669050119:45,515,248C/T—uncertain significance
rs76508833219:45,515,249G/T—benign
rs121332227219:45,515,252C/A—likely benign
rs124983947519:45,515,253C/G—uncertain significance
rs75026232019:45,515,254C/G—uncertain significance
rs143136532919:45,515,258C/T—uncertain significance
rs143598625719:45,515,265C/T—likely benign
rs76594889019:45,515,269C/T—uncertain significance
rs251363813219:45,515,270A/G—likely benign
rs136949635519:45,515,272G/A—uncertain significance
rs75129020519:45,515,276G/A—likely benign
rs75443203419:45,515,280T/C—uncertain significance
rs75317107619:45,515,293C/T—uncertain significance
rs75663625919:45,515,294G/A—likely benign
rs57178677119:45,515,305C/T—uncertain significance
rs74965685119:45,515,306G/A—likely benign
rs145520400919:45,515,312C/T—likely benign
rs138923941819:45,515,319C/A—uncertain significance
rs77898814819:45,515,325G/T—uncertain significance
rs117162491419:45,515,326C/T—uncertain significance
rs129548570719:45,515,342G/A—likely benign
rs77573899519:45,515,344C/T—uncertain significance
rs37063543719:45,515,345G/A—likely benign
rs251363828719:45,515,354C/T—likely benign
rs197136774919:45,515,355T/A—uncertain significance
rs101240063119:45,515,364G/A—uncertain significance
rs76265346219:45,515,367C/G—uncertain significance
rs251363832219:45,515,368G/A—uncertain significance
rs251363833419:45,515,377C/T—uncertain significance
rs75927481719:45,515,386C/T—uncertain significance
rs3533620419:45,515,387G/A—benign
rs251363837019:45,515,391C/G—uncertain significance
rs37633154219:45,515,392C/T—uncertain significance
rs77937211219:45,515,404C/T—uncertain significance
rs102307756819:45,515,419C/T—uncertain significance
rs103144530919:45,515,432G/A—likely benign
rs14842207919:45,515,435G/A—likely benign
rs251363849119:45,515,451C/T—uncertain significance
rs77060320819:45,515,456C/T—likely benign
rs137198740019:45,515,495G/T—uncertain significance
rs76016315019:45,515,511A/G—uncertain significance
rs118264737019:45,515,517A/G—uncertain significance
rs37511952319:45,515,519G/A—likely benign

Showing 100 of 347 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.