rs642803
This is a regulatory region variant variant in the OVOL1 gene.
▶GWAS Catalog Trait Associations (8)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (8)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
gout
Major TJ et al. “A genome-wide association analysis reveals new pathogenic pathways in gout.” Nature Genetics 56(11):2392-2406 (2024)
Allele T
OR 0.91
p 6.0e-87
N 2,206,883
Large GWAS
European
uric acid measurement
Nakatochi M et al. “Genome-wide meta-analysis identifies multiple novel loci associated with serum uric acid levels in Japanese individuals.” Communications Biology 2:115 (2019)
Allele T
OR 0.04
p 1.0e-24
N 121,745
Meta-analysisLarge GWAS
multi-ancestry
beta-1,4-glucuronyltransferase 1 measurement
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele T
OR 0.04
p 2.0e-14
N 47,745
Large GWAS
European
urate measurement
Köttgen A et al. “Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.” Nature Genetics 45(2):145-54 (2013)
Allele T
OR 0.04
p 3.0e-13
N 110,347
Large GWAS
European
high density lipoprotein cholesterol measurement
Lind L et al. “Genetic Determinants of Clustering of Cardiometabolic Risk Factors in U.K. Biobank.” Metabolic Syndrome and Related Disorders 18(3):121-127 (2020)
Allele T
OR 0.01
p 5.0e-11
N 291,107
Large GWAS
European
low density lipoprotein cholesterol measurement
Graham SE et al. “The power of genetic diversity in genome-wide association studies of lipids.” Nature 600(7890):675-679 (2021)
Allele T
OR 0.01
p 4.0e-10
N 1,320,016
Large GWAS
European
self reported educational attainment
Lee JJ et al. “Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.” Nature Genetics 50(8):1112-1121 (2018)
Allele T
OR 0.01
p 2.0e-8
N 1,311,438
Large GWAS
European
mathematical ability
Lee JJ et al. “Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.” Nature Genetics 50(8):1112-1121 (2018)
Allele T
OR 0.01
p 4.0e-8
N 811,539
Large GWAS
European
About OVOL1
This gene encodes a putative zinc finger containing transcription factor that is highly similar to homologous protein in Drosophila and mouse. Based on known functions in these species, this protein is likely involved in hair formation and spermatogenesis in human as well. [provided by RefSeq, Aug 2011]
View all OVOL1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
Community Wiki
No community notes yet for this variant. Sign in to start one.
Comments
Sign in to join the discussion.
Loading comments…