rs7350481
▶GWAS Catalog Trait Associations (6)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (6)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
triglyceride measurement
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.25
p 9.9e-324
N 558,939
Major Consortium StudyLarge GWAS
multi-ancestry
Klarin D et al. “Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.” Nature Genetics 50(11):1514-1523 (2018)
Allele T
OR 0.23
p 1.0e-300
N 297,626
Major Consortium StudyLarge GWAS
multi-ancestry
Huang QQ et al. “Transferability of genetic loci and polygenic scores for cardiometabolic traits in British Pakistani and Bangladeshi individuals.” Nature Communications 13(1):4664 (2022)
Allele T
OR 0.24
p 7.0e-62
N 22,000
Large GWAS
South Asian
Kamatani Y et al. “Genome-wide association study of hematological and biochemical traits in a Japanese population.” Nature Genetics 42(3):210-5 (2010)
Allele T
OR 0.24
p 1.0e-49
N 8,993
Large GWAS
East Asian
Zhu Y et al. “Susceptibility loci for metabolic syndrome and metabolic components identified in Han Chinese: a multi-stage genome-wide association study.” Journal of Cellular and Molecular Medicine 21(6):1106-1116 (2017)
Allele T
OR 0.04
p 5.0e-9
N 1,742
Large GWAS
East Asian
Bandesh K et al. “Genome-wide association study of blood lipids in Indians confirms universality of established variants.” Journal of Human Genetics 64(6):573-587 (2019)
Allele T
OR 16.32
p 1.0e-20
N 1,036
Large GWAS
multi-ancestry
metabolic syndrome
Ho CY et al. “A Genome-Wide Association Study of Metabolic Syndrome in the Taiwanese Population.” Nutrients 16(1) (2023)
Allele C
OR 0.24
p 1.0e-85
N 107,230
Large GWAS
East Asian
high density lipoprotein cholesterol measurement
Huang QQ et al. “Transferability of genetic loci and polygenic scores for cardiometabolic traits in British Pakistani and Bangladeshi individuals.” Nature Communications 13(1):4664 (2022)
Allele C
OR 0.10
p 8.0e-14
N 22,000
Large GWAS
South Asian
Kamatani Y et al. “Genome-wide association study of hematological and biochemical traits in a Japanese population.” Nature Genetics 42(3):210-5 (2010)
Allele C
OR 0.12
p 9.0e-10
N 14,402
Large GWAS
East Asian
lipid measurement
Jeon S et al. “Korea4K: whole genome sequences of 4,157 Koreans with 107 phenotypes derived from extensive health check-ups.” Gigascience 13 (2024)
Allele T
OR 0.26
p 3.0e-13
N 2,321
Large GWAS
East Asian
free cholesterol in IDL measurement
Davyson E et al. “Metabolomic Investigation of Major Depressive Disorder Identifies a Potentially Causal Association With Polyunsaturated Fatty Acids.” Biological Psychiatry 94(8):630-639 (2023)
Allele T
OR 0.06
p 3.0e-11
N 88,329
Large GWAS
European
total cholesterol measurement
Huang QQ et al. “Transferability of genetic loci and polygenic scores for cardiometabolic traits in British Pakistani and Bangladeshi individuals.” Nature Communications 13(1):4664 (2022)
Allele C
OR 0.09
p 1.0e-10
N 22,000
Large GWAS
South Asian
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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