rs7552

This variant is located in the CYRIA gene.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

Cleft palate, cleft lip

Yu Y et al. “Genome-wide analyses of non-syndromic cleft lip with palate identify 14 novel loci and genetic heterogeneity.” Nature Communications 8:14364 (2017)

Allele G

OR 1.37

p 6.0e-22

N 6,084

Large GWAS

East Asian

cleft lip

Huang L et al. “Genetic factors define CPO and CLO subtypes of nonsyndromicorofacial cleft.” Plos Genetics 15(10):e1008357 (2019)

Allele G

OR 1.56

p 6.0e-17

N 5,993

Large GWAS

East Asian

nephrolithiasis

Cao X et al. “Trans-ancestry GWAS identifies 59 loci and improves risk prediction and fine-mapping for kidney stone disease.” Nature Communications 16(1):3473 (2025)

Allele A

OR 1.05

p 4.0e-8

N 975,370

Large GWAS

multi-ancestry

About CYRIA

Predicted to enable small GTPase binding activity. Predicted to be involved in regulation of actin filament polymerization. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

View all CYRIA variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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