rs7859727

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GWAS Catalog Trait Associations (9)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

heart failure

Lee DSM et al. “Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum.” Nature Genetics 57(4):829-838 (2025)
Allele T
OR 0.05
p 3.0e-40
N 2,358,556
Large GWAS
multi-ancestry
Enzan N et al. “Genome-wide analysis of heart failure yields insights into disease heterogeneity and enables prognostic prediction in the Japanese population.” Nature Communications 16(1):9680 (2025)
Allele T
OR 0.04
p 5.0e-18
N 1,672,415
Large GWAS
multi-ancestry
Levin MG et al. “Genome-wide association and multi-trait analyses characterize the common genetic architecture of heart failure.” Nature Communications 13(1):6914 (2022)
Allele T
OR 0.05
p 3.0e-31
N 1,665,481
Large GWAS
multi-ancestry
Rasooly D et al. “Genome-wide association analysis and Mendelian randomization proteomics identify drug targets for heart failure.” Nature Communications 14(1):3826 (2023)
Allele T
OR 0.06
p 3.0e-29
N 1,279,610
Large GWAS
European

aging

Rosoff DB et al. “Multivariate genome-wide analysis of aging-related traits identifies novel loci and new drug targets for healthy aging.” Nature Aging 3(8):1020-1035 (2023)
Allele C
OR 0.01
p 3.0e-18
N 1,559,001
Large GWAS
European

healthspan, parental longevity, life span determination trait

Timmers PRHJ et al. “Multivariate genomic scan implicates novel loci and haem metabolism in human ageing.” Nature Communications 11(1):3570 (2020)
Allele C
OR —
p 4.0e-18
N 837,415
Large GWAS
European

device complication

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.14
p 2.0e-17
N 622,286
Major Consortium StudyLarge GWAS
multi-ancestry

cardioverter defibrillator

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.10
p 8.0e-14
N 629,819
Major Consortium StudyLarge GWAS
multi-ancestry

cardiovascular disease

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.07
p 1.0e-11
N 595,817
Major Consortium StudyLarge GWAS
multi-ancestry

Ischemic stroke

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele T
OR 0.06
p 5.0e-11
N 658,807
Large GWAS
multi-ancestry

healthspan

Zenin A et al. “Identification of 12 genetic loci associated with human healthspan.” Communications Biology 2:41 (2019)
Allele T
OR 0.03
p 3.0e-10
N 300,447
Large GWAS
multi-ancestry

asthma, endometriosis

Adewuyi EO et al. “Genetic overlap analysis of endometriosis and asthma identifies shared loci implicating sex hormones and thyroid signalling pathways.” Human Reproduction (oxford, England) 37(2):366-383 (2022)
Allele C
OR —
β 0.052
p 1.0e-8
N 519,828
Large GWAS
East Asian, European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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