Trait
SNPs associated with Decreased HDL cholesterol concentration
20 genetic variants across 10 genes have been associated with Decreased HDL cholesterol concentration in published research. Key genes include ABCA1, AKT1, APOA5.
Associated variants20 total
| rsid | Gene | Effect | Evidence |
|---|---|---|---|
| rs1077835 | LIPC | GWAS association (p=2.0e-87) | Large GWAS |
| rs429358 | APOE | GWAS association (p=2.0e-43) | Large GWAS |
| rs2494746 | AKT1 | GWAS association (p=2.0e-11) | Large GWAS |
| rs36145916 | — | GWAS association (p=3.0e-10) | Large GWAS |
| rs4821130 | — | GWAS association (p=8.0e-10) | Large GWAS |
| rs10787431 | GPAM | GWAS association (p=9.0e-10) | Large GWAS |
| rs10773112 | — | GWAS association (p=1.0e-09) | Large GWAS |
| rs1180648 | TRPS1 | GWAS association (p=2.0e-09) | Large GWAS |
| rs140639155 | — | GWAS association (p=9.0e-09) | Large GWAS |
| rs10422861 | PEPD | GWAS association (p=9.0e-09) | Large GWAS |
| rs34063748 | — | GWAS association (p=2.0e-08) | Large GWAS |
| rs78000468 | — | GWAS association (p=2.0e-08) | Large GWAS |
| rs12037073 | — | GWAS association (p=4.0e-08) | Large GWAS |
| rs6467314 | — | GWAS association (p=5.0e-08) | Large GWAS |
| rs36229491 | — | GWAS association (p=2.0e-178) | Large GWAS |
| rs9953437 | LIPG | GWAS association (p=4.0e-43) | Large GWAS |
| rs17410996 | — | GWAS association (p=2.0e-53) | Large GWAS |
| rs2575876 | ABCA1 | GWAS association (p=3.0e-33) | Large GWAS |
| rs2075291 | APOA5 | GWAS association (p=4.0e-164) | Large GWAS |
| rs75326924 | CD36 | GWAS association (p=3.0e-16) | Large GWAS |
Associations aggregated from the GWAS Catalog and curated literature. Informational only — not medical advice.