CNOT1

CCR4-NOT transcription complex subunit 1

Summary

Enables armadillo repeat domain binding activity; molecular adaptor activity; and nuclear receptor binding activity. Contributes to poly(A)-specific ribonuclease activity. Involved in several processes, including negative regulation of intracellular signal transduction; positive regulation of cytoplasmic mRNA processing body assembly; and regulation of gene expression. Located in P-body and cytosol. Part of CCR4-NOT complex. Implicated in Vissers-Bodmer syndrome and holoprosencephaly 12. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants509 total

rsidPosition (GRCh37)AllelesClassClinVar
rs1782154916:58,554,780C/T—benign
rs11232585816:58,554,904C/T—likely benign
rs18876463216:58,554,925G/A—benign
rs37002373816:58,555,092G/A—likely benign
rs254378684716:58,555,119A/T—uncertain significance
rs37273610016:58,555,131C/T—likely benign
rs254378698316:58,555,169T/G—likely pathogenic
rs254378699516:58,555,174A/C—uncertain significance
rs254378700416:58,555,175G/C—uncertain significance
rs74926006416:58,555,237A/C—likely benign
rs20070756416:58,557,267C/T—likely benign
rs19969425916:58,557,300C/G—likely benign
rs254380294816:58,557,338T/C—uncertain significance
rs15019529816:58,557,339G/A—likely benign
rs1164469416:58,557,342A/G—benign
rs76042158716:58,557,372C/G—uncertain significance
rs95817646516:58,557,400T/G—uncertain significance
rs3705416:58,558,989C/T—benign
rs14933858416:58,559,072G/A—benign
rs254381140516:58,559,086C/T—uncertain significance
rs74812243216:58,559,152T/A—uncertain significance
rs116918227716:58,559,162G/A—likely benign
rs142665530716:58,559,172T/C—uncertain significance
rs254381159216:58,559,184G/A—uncertain significance
rs254381160816:58,559,192C/T—likely benign
rs254381161816:58,559,194G/C—uncertain significance
rs118446005416:58,559,220T/C—uncertain significance
rs124272030616:58,559,235T/G—uncertain significance
rs101386921216:58,559,242G/A—uncertain significance
rs14953522216:58,559,256T/C—likely benign
rs1259620516:58,559,414C/T—benign
rs224156916:58,559,629T/Cintron variant—
rs75674741816:58,559,875T/G—likely benign
rs254381479116:58,559,876A/T—likely benign
rs254381488416:58,559,890A/T—uncertain significance
rs18790791716:58,559,899G/T—uncertain significance
rs57782115816:58,559,920G/A—likely benign
rs119779985016:58,559,939G/C—uncertain significance
rs254381502316:58,559,947A/G—likely benign
rs203957120616:58,559,950G/A—likely benign
rs13974172616:58,559,971C/T—likely benign
rs20068935016:58,559,976G/A—likely benign
rs254381519716:58,560,029C/T—uncertain significance
rs19180509416:58,560,051G/C—benign
rs2846850216:58,560,205G/C—benign
rs7453005916:58,562,360T/A—benign
rs18945809416:58,562,367T/C—benign
rs37733046516:58,562,403G/A—likely benign
rs215189877816:58,562,405G/A—uncertain significance
rs254382954616:58,562,410C/T—uncertain significance
rs76061263816:58,562,427G/A—likely benign
rs13990892916:58,562,451C/T—benign
rs159739918216:58,562,488T/C—uncertain significance
rs254382978316:58,562,543T/C—uncertain significance
rs78009072816:58,564,131A/G—likely benign
rs103755729516:58,564,201C/T—likely benign
rs215190194216:58,564,253T/C—likely pathogenic
rs75521731416:58,564,258G/A—likely benign
rs254383872316:58,564,262G/T—likely benign
rs37658918016:58,564,267G/A—benign
rs77074796316:58,564,268T/C—likely benign
rs93975180716:58,565,851T/C—likely benign
rs254384560916:58,565,854A/C—likely benign
rs77915973016:58,565,871T/C—likely benign
rs20122696016:58,565,874C/G—likely benign
rs139470118316:58,565,875G/A—uncertain significance
rs215190434616:58,565,906G/A—uncertain significance
rs254384574616:58,565,924G/T—uncertain significance
rs14619999616:58,565,928G/A—likely benign
rs11811468816:58,566,119G/A—benign
rs89190244716:58,566,128A/G—likely benign
rs76225042116:58,566,189A/G—likely benign
rs77999276916:58,566,190T/C—likely benign
rs254384702616:58,566,253C/T—uncertain significance
rs254384704216:58,566,262T/C—uncertain significance
rs254384708316:58,566,283A/G—uncertain significance
rs254384709916:58,566,297G/A—likely benign
rs3706016:58,566,304G/Asplice region variantbenign
rs74771937116:58,566,315A/G—likely benign
rs3706216:58,567,238A/Gintron variant—
rs20129980316:58,568,042A/G—benign
rs122851456316:58,568,047A/G—uncertain significance
rs13921157916:58,568,059G/A—likely benign
rs254385552516:58,568,099G/A—likely benign
rs105711260716:58,568,108G/A—likely benign
rs1696022316:58,568,117A/G—benign
rs203986257716:58,568,181G/A—uncertain significance
rs37112812416:58,568,219G/A—likely benign
rs254385587816:58,568,241C/A—uncertain significance
rs86841297716:58,568,248G/C—uncertain significance
rs13947830316:58,568,273G/A—likely benign
rs20032977916:58,568,318A/G—likely benign
rs77351272716:58,570,915G/A—uncertain significance
rs77539947116:58,570,929G/A—likely benign
rs76287721616:58,570,932G/A—likely benign
rs254386707216:58,570,951T/C—uncertain significance
rs254386707516:58,570,953G/C—likely benign
rs127011445216:58,570,965T/C—likely benign
rs254386712816:58,570,983T/C—likely benign
rs254386714916:58,570,993C/T—uncertain significance

Showing 100 of 509 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.