CYP4F2
cytochrome P450 family 4 subfamily F member 2
Pharmacogene
Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F11, is approximately 16 kb away. [provided by RefSeq, Jul 2008]
Known Variants64 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1272 | 19:15,989,040 | G/C | 3 prime UTR variant | — |
| rs2512624494 | 19:15,989,573 | T/C | — | likely benign |
| rs3093200 | 19:15,989,589 | G/T | missense variant | likely benign |
| rs2512624550 | 19:15,989,601 | G/T | — | likely benign |
| rs2089322394 | 19:15,989,642 | T/C | — | uncertain significance |
| rs2512624698 | 19:15,989,658 | T/C | — | uncertain significance |
| rs150488576 | 19:15,989,674 | G/A | — | likely benign |
| rs143677430 | 19:15,989,675 | C/T | — | uncertain significance |
| rs368748953 | 19:15,989,701 | G/A | — | likely benign |
| rs143088581 | 19:15,989,708 | T/G | — | uncertain significance |
| rs4020346 | 19:15,989,730 | T/C | — | likely benign |
| rs138905922 | 19:15,989,750 | G/C | — | benign |
| rs764508037 | 19:15,990,211 | C/T | — | uncertain significance |
| rs2108622 | 19:15,990,431 | C/T | missense | drug response |
| rs780094643 | 19:15,990,478 | C/A | — | uncertain significance |
| rs143888844 | 19:15,990,581 | G/A | — | likely benign |
| rs141338395 | 19:15,990,698 | C/T | — | benign |
| rs2512626593 | 19:15,990,707 | C/A | — | uncertain significance |
| rs3093161 | 19:15,996,724 | C/T | — | benign |
| rs200373927 | 19:15,996,756 | G/A | — | uncertain significance |
| rs146776687 | 19:15,996,757 | G/A | — | likely benign |
| rs868591807 | 19:15,996,795 | C/T | — | uncertain significance |
| rs2074900 | 19:15,996,820 | G/A | — | benign |
| rs145174239 | 19:15,996,828 | G/C | — | benign |
| rs2512631603 | 19:15,996,834 | A/G | — | uncertain significance |
| rs757642625 | 19:15,996,851 | G/A | — | uncertain significance |
| rs144811674 | 19:15,997,081 | C/A | — | uncertain significance |
| rs1371783725 | 19:15,997,091 | C/T | — | uncertain significance |
| rs201836634 | 19:15,997,127 | A/C | — | likely benign |
| rs1558139 | 19:15,997,564 | G/A | intron variant | — |
| rs3093158 | 19:16,000,166 | C/G | — | — |
| rs3093157 | 19:16,000,320 | A/G | — | likely benign |
| rs529347632 | 19:16,000,357 | T/C | — | uncertain significance |
| rs147434380 | 19:16,000,359 | G/A | — | likely benign |
| rs200485245 | 19:16,000,388 | G/A | — | uncertain significance |
| rs1568472327 | 19:16,000,438 | T/C | — | uncertain significance |
| rs3093221 | 19:16,000,510 | G/T | — | conflicting classifications of pathogenicity |
| rs3093153 | 19:16,001,215 | C/A | — | benign |
| rs769698813 | 19:16,003,124 | T/G | — | uncertain significance |
| rs754089074 | 19:16,003,183 | G/A | — | uncertain significance |
| rs1449702446 | 19:16,003,187 | G/T | — | uncertain significance |
| rs780906704 | 19:16,003,199 | G/A | — | uncertain significance |
| rs149607948 | 19:16,003,344 | C/A | — | uncertain significance |
| rs145875499 | 19:16,003,351 | C/T | — | likely benign |
| rs1007657184 | 19:16,003,376 | C/A | — | uncertain significance |
| rs1177436484 | 19:16,003,383 | G/A | — | uncertain significance |
| rs3093136 | 19:16,003,388 | G/C | — | benign |
| rs3093135 | 19:16,004,371 | A/T | regulatory region variant | — |
| rs769154455 | 19:16,006,310 | T/C | — | likely benign |
| rs8110714 | 19:16,006,323 | G/A | — | benign |
| rs372270252 | 19:16,006,346 | C/A | — | uncertain significance |
| rs8100960 | 19:16,006,380 | T/G | — | benign |
| rs1471896721 | 19:16,006,394 | T/C | — | uncertain significance |
| rs3093114 | 19:16,006,413 | G/A | — | benign |
| rs188418586 | 19:16,006,419 | C/A | — | likely benign |
| rs2074902 | 19:16,008,099 | T/C | intron variant | — |
| rs868834988 | 19:16,008,252 | C/T | — | uncertain significance |
| rs3093106 | 19:16,008,257 | C/T | — | benign |
| rs559132777 | 19:16,008,286 | G/A | — | uncertain significance |
| rs139237854 | 19:16,008,323 | A/G | — | likely benign |
| rs776637825 | 19:16,008,352 | G/T | — | uncertain significance |
| rs114099324 | 19:16,008,376 | C/G | — | benign |
| rs3093105 | 19:16,008,388 | A/C | missense variant | — |
| rs3093098 | 19:16,008,512 | A/G | downstream gene variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.