DVL2

dishevelled segment polarity protein 2

Summary

This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. [provided by RefSeq, Jul 2008]

Known Variants60 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs2508384757	17:7,129,189	T/A	—	uncertain significance
rs766166785	17:7,129,210	T/G	—	uncertain significance
rs752593583	17:7,129,299	G/A	—	uncertain significance
rs757957085	17:7,129,509	C/T	—	uncertain significance
rs779788537	17:7,129,515	C/T	—	uncertain significance
rs2508388400	17:7,129,564	C/A	—	uncertain significance
rs2508388465	17:7,129,569	T/C	—	uncertain significance
rs781121098	17:7,129,581	C/G	—	uncertain significance
rs776949531	17:7,129,599	C/G	—	uncertain significance
rs973083666	17:7,129,775	T/C	—	uncertain significance
rs747066639	17:7,129,778	G/A	—	uncertain significance
rs201803378	17:7,129,797	G/A	—	uncertain significance
rs35594616	17:7,129,840	T/C	—	benign
rs565161291	17:7,129,844	T/A	—	uncertain significance
rs72839768	17:7,129,898	A/G	—	benign
rs2074222	17:7,129,974	A/G	—	benign
rs758763721	17:7,130,538	G/A	—	uncertain significance
rs369536247	17:7,130,828	G/A	—	uncertain significance
rs147661282	17:7,130,831	C/A	—	uncertain significance
rs149100313	17:7,130,842	C/T	—	benign
rs756683592	17:7,130,843	G/A	—	uncertain significance
rs2071479961	17:7,131,052	C/T	—	uncertain significance
rs767229371	17:7,131,337	C/T	—	uncertain significance
rs62059164	17:7,131,371	G/A	—	benign
rs148354072	17:7,132,304	T/C	—	uncertain significance
rs369818238	17:7,132,355	T/A	—	uncertain significance
rs148777337	17:7,132,460	A/G	—	benign
rs766732685	17:7,132,480	T/C	—	uncertain significance
rs2508409624	17:7,132,529	G/C	—	uncertain significance
rs199741414	17:7,132,724	T/C	—	uncertain significance
rs753072149	17:7,132,764	C/T	—	likely benign
rs201343725	17:7,132,774	G/A	—	likely benign
rs940773303	17:7,133,119	A/C	—	likely benign
rs1020549764	17:7,133,136	G/A	—	uncertain significance
rs903803977	17:7,133,147	G/C	—	uncertain significance
rs548574495	17:7,133,161	G/C	—	uncertain significance
rs222836	17:7,133,162	A/G	—	benign
rs146424893	17:7,133,204	C/T	—	likely benign
rs956522691	17:7,133,224	G/A	—	uncertain significance
rs11549559	17:7,133,241	C/T	—	uncertain significance
rs374072094	17:7,133,404	G/A	—	uncertain significance
rs768843844	17:7,133,443	C/G	—	uncertain significance
rs62059165	17:7,133,594	A/G	—	benign
rs2074216	17:7,133,609	A/G	—	benign
rs771185372	17:7,133,631	A/G	—	uncertain significance
rs772512773	17:7,133,640	G/A	—	uncertain significance
rs374951296	17:7,133,658	G/A	—	uncertain significance
rs371764720	17:7,133,682	G/A	—	likely benign
rs1261612115	17:7,133,713	G/A	—	uncertain significance
rs376639739	17:7,133,725	G/A	—	uncertain significance
rs143043931	17:7,134,081	C/T	—	likely benign
rs150823721	17:7,134,098	A/T	—	likely benign
rs139652472	17:7,137,404	T/C	—	uncertain significance
rs149736410	17:7,137,424	G/A	—	likely benign
rs139256869	17:7,137,476	C/G	—	uncertain significance
rs2508433593	17:7,137,529	T/C	—	uncertain significance
rs754572995	17:7,137,550	A/G	—	uncertain significance
rs146467021	17:7,137,558	G/A	—	likely benign
rs2508433924	17:7,137,568	C/A	—	uncertain significance
rs751727843	17:7,137,585	C/G	—	likely benign

Gene information from NCBI Gene. Variant classifications from ClinVar.