GRK4
G protein-coupled receptor kinase 4
Pharmacogene
Summary
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
Known Variants48 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs73792114 | 4:2,976,504 | G/A | intron variant | — |
| rs191361200 | 4:2,986,296 | C/A | — | uncertain significance |
| rs2474770046 | 4:2,986,305 | A/C | — | uncertain significance |
| rs372027080 | 4:2,990,498 | C/T | — | uncertain significance |
| rs2960306 | 4:2,990,499 | G/A | missense variant | — |
| rs142548315 | 4:2,990,546 | A/G | — | uncertain significance |
| rs936911191 | 4:2,990,556 | T/C | — | uncertain significance |
| rs2995803 | 4:2,990,864 | C/G | — | — |
| rs142478577 | 4:2,994,002 | A/C | — | likely benign |
| rs1340127073 | 4:2,994,003 | G/A | — | uncertain significance |
| rs368709515 | 4:3,006,026 | G/T | — | uncertain significance |
| rs749248762 | 4:3,006,030 | C/T | — | uncertain significance |
| rs1024323 | 4:3,006,043 | C/T | missense | — |
| rs138100796 | 4:3,009,471 | A/G | — | uncertain significance |
| rs2475147019 | 4:3,009,491 | C/G | — | uncertain significance |
| rs117478149 | 4:3,009,536 | C/T | — | benign |
| rs141282743 | 4:3,011,382 | G/A | — | uncertain significance |
| rs45538934 | 4:3,011,386 | C/G | — | uncertain significance |
| rs572038787 | 4:3,015,421 | G/A | — | uncertain significance |
| rs775540841 | 4:3,015,458 | G/T | — | uncertain significance |
| rs2475270643 | 4:3,015,491 | G/A | — | uncertain significance |
| rs745989304 | 4:3,015,542 | A/G | — | uncertain significance |
| rs71608251 | 4:3,017,462 | A/G | intron variant | — |
| rs201271230 | 4:3,021,391 | A/C | — | uncertain significance |
| rs1261047806 | 4:3,021,402 | C/G | — | uncertain significance |
| rs2475391491 | 4:3,021,449 | C/T | — | uncertain significance |
| rs757656701 | 4:3,021,473 | G/A | — | uncertain significance |
| rs185967676 | 4:3,021,475 | C/T | — | benign |
| rs1341650343 | 4:3,021,527 | G/A | — | uncertain significance |
| rs139428941 | 4:3,024,158 | A/C | — | uncertain significance |
| rs200471975 | 4:3,029,659 | C/T | — | uncertain significance |
| rs2475539833 | 4:3,029,669 | C/G | — | uncertain significance |
| rs1738047202 | 4:3,029,693 | G/C | — | likely benign |
| rs561361379 | 4:3,029,718 | C/T | — | likely benign |
| rs1324708245 | 4:3,030,933 | G/A | — | uncertain significance |
| rs759552478 | 4:3,031,086 | G/A | — | uncertain significance |
| rs144771780 | 4:3,031,129 | G/A | — | uncertain significance |
| rs531917979 | 4:3,034,128 | C/A | — | — |
| rs933402818 | 4:3,037,170 | G/A | — | uncertain significance |
| rs200216453 | 4:3,037,225 | T/C | — | uncertain significance |
| rs1377359706 | 4:3,039,129 | T/C | — | uncertain significance |
| rs1801058 | 4:3,039,150 | T/C | missense | — |
| rs778721346 | 4:3,039,158 | G/A | — | uncertain significance |
| rs2475699568 | 4:3,039,168 | T/G | — | uncertain significance |
| rs928806558 | 4:3,039,188 | T/C | — | uncertain significance |
| rs771220706 | 4:3,039,197 | C/T | — | uncertain significance |
| rs764069331 | 4:3,039,231 | A/C | — | uncertain significance |
| rs377270614 | 4:3,042,317 | C/T | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.