INPP5B
inositol polyphosphate-5-phosphatase B
Summary
This gene encodes a member of a family of inositol polyphosphate-5-phosphatases. These enzymes function in the regulation of calcium signaling by inactivating inositol phosphates. The encoded protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jul 2014]
Known Variants103 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs3843 | 1:38,327,982 | G/T | — | benign |
| rs561088456 | 1:38,328,030 | T/G | — | uncertain significance |
| rs529874480 | 1:38,328,031 | T/C | — | uncertain significance |
| rs373776316 | 1:38,328,061 | G/A | — | uncertain significance |
| rs28542272 | 1:38,328,154 | G/T | — | benign |
| rs41311191 | 1:38,329,999 | C/G | — | benign |
| rs772317418 | 1:38,330,034 | C/T | — | likely benign |
| rs1399521521 | 1:38,330,056 | G/A | — | uncertain significance |
| rs755081175 | 1:38,330,077 | T/G | — | uncertain significance |
| rs1477995585 | 1:38,331,465 | C/T | — | uncertain significance |
| rs758700003 | 1:38,331,495 | T/C | — | uncertain significance |
| rs1164629396 | 1:38,331,558 | C/A | — | uncertain significance |
| rs4653332 | 1:38,331,799 | C/G | — | benign |
| rs760192436 | 1:38,332,140 | C/T | — | uncertain significance |
| rs750222005 | 1:38,332,198 | T/A | — | uncertain significance |
| rs1371433291 | 1:38,334,193 | A/G | — | uncertain significance |
| rs757765937 | 1:38,334,271 | A/T | — | likely benign |
| rs2306425 | 1:38,334,317 | T/A | — | benign |
| rs2306426 | 1:38,334,318 | C/A | — | benign |
| rs771766555 | 1:38,338,649 | T/C | — | uncertain significance |
| rs368417324 | 1:38,338,663 | T/G | — | uncertain significance |
| rs376320485 | 1:38,338,745 | C/T | — | uncertain significance |
| rs200372916 | 1:38,338,760 | T/A | — | uncertain significance |
| rs11488569 | 1:38,338,795 | A/G | — | benign |
| rs973411972 | 1:38,338,828 | A/G | — | uncertain significance |
| rs148711435 | 1:38,339,659 | C/T | — | benign |
| rs373428823 | 1:38,339,773 | G/A | — | uncertain significance |
| rs777690297 | 1:38,341,291 | A/C | — | uncertain significance |
| rs758689721 | 1:38,341,298 | C/G | — | uncertain significance |
| rs377554015 | 1:38,341,373 | C/T | — | uncertain significance |
| rs12752414 | 1:38,341,518 | G/A | — | benign |
| rs60439773 | 1:38,341,616 | C/A | — | benign |
| rs141357169 | 1:38,343,863 | G/A | — | likely benign |
| rs374124248 | 1:38,343,936 | G/A | — | uncertain significance |
| rs780542769 | 1:38,345,781 | G/A | — | uncertain significance |
| rs2306427 | 1:38,345,896 | A/C | — | benign |
| rs41307896 | 1:38,348,506 | G/A | — | benign |
| rs373523453 | 1:38,348,508 | C/T | — | uncertain significance |
| rs764793515 | 1:38,351,316 | T/C | — | uncertain significance |
| rs754183601 | 1:38,351,361 | T/C | — | uncertain significance |
| rs780652276 | 1:38,351,416 | T/C | — | uncertain significance |
| rs202204967 | 1:38,351,443 | C/T | — | likely benign |
| rs1365635174 | 1:38,351,482 | C/T | — | uncertain significance |
| rs763776051 | 1:38,352,592 | C/T | — | uncertain significance |
| rs200506068 | 1:38,352,593 | G/A | — | likely benign |
| rs2525094266 | 1:38,352,615 | G/A | — | uncertain significance |
| rs2279261 | 1:38,352,849 | G/C | — | benign |
| rs753273148 | 1:38,353,071 | C/A | — | uncertain significance |
| rs139833474 | 1:38,353,074 | C/T | — | likely benign |
| rs56023437 | 1:38,353,403 | C/T | downstream gene variant | — |
| rs1429299332 | 1:38,353,939 | T/G | — | uncertain significance |
| rs28580141 | 1:38,353,941 | T/G | — | benign |
| rs4652970 | 1:38,354,246 | G/A | — | benign |
| rs2291161 | 1:38,355,103 | G/T | — | benign |
| rs751225260 | 1:38,355,270 | T/C | — | likely benign |
| rs757103552 | 1:38,355,312 | C/A | — | uncertain significance |
| rs2525140224 | 1:38,355,344 | T/C | — | uncertain significance |
| rs760232417 | 1:38,355,377 | C/T | — | uncertain significance |
| rs61776667 | 1:38,355,520 | A/G | — | benign |
| rs34349547 | 1:38,356,870 | G/C | — | benign |
| rs1047242711 | 1:38,357,046 | C/G | — | uncertain significance |
| rs773547437 | 1:38,357,118 | T/C | — | uncertain significance |
| rs1006207213 | 1:38,357,120 | G/A | — | uncertain significance |
| rs35978921 | 1:38,361,215 | C/T | intron variant | — |
| rs61776676 | 1:38,364,229 | C/T | intron variant | — |
| rs9729284 | 1:38,373,989 | C/G | — | — |
| rs61776678 | 1:38,377,021 | G/A | intron variant | — |
| rs35267671 | 1:38,397,369 | C/T | — | benign |
| rs142849696 | 1:38,397,370 | G/A | — | benign |
| rs371536609 | 1:38,397,372 | C/A | — | benign |
| rs61751228 | 1:38,397,524 | C/T | — | benign |
| rs765680489 | 1:38,397,660 | C/T | — | uncertain significance |
| rs777338724 | 1:38,397,710 | G/A | — | uncertain significance |
| rs76849367 | 1:38,397,821 | C/T | — | benign |
| rs28605759 | 1:38,399,816 | G/A | intron variant | — |
| rs376311253 | 1:38,406,382 | G/A | — | likely benign |
| rs200111067 | 1:38,406,456 | C/T | — | uncertain significance |
| rs28600729 | 1:38,406,626 | A/G | — | benign |
| rs28570969 | 1:38,407,146 | A/C | — | — |
| rs28380108 | 1:38,409,103 | G/C | — | benign |
| rs28416760 | 1:38,409,112 | T/A | — | benign |
| rs201533855 | 1:38,409,317 | A/T | — | benign |
| rs114328240 | 1:38,409,395 | C/T | — | benign |
| rs749232995 | 1:38,409,479 | G/A | — | uncertain significance |
| rs200033881 | 1:38,409,491 | G/A | — | uncertain significance |
| rs1320200017 | 1:38,409,533 | A/G | — | uncertain significance |
| rs61580780 | 1:38,409,616 | G/A | — | benign |
| rs78122794 | 1:38,409,635 | G/A | — | benign |
| rs61776701 | 1:38,411,275 | A/G | — | benign |
| rs11485595 | 1:38,411,350 | C/T | — | benign |
| rs773387490 | 1:38,411,428 | G/A | — | likely pathogenic |
| rs56993041 | 1:38,411,444 | C/T | — | benign |
| rs871524 | 1:38,411,445 | G/A | — | benign |
| rs185569565 | 1:38,411,455 | C/T | — | uncertain significance |
| rs182465254 | 1:38,411,489 | G/C | — | uncertain significance |
| rs1395286033 | 1:38,411,521 | G/A | — | uncertain significance |
| rs61751229 | 1:38,411,527 | G/A | — | benign |
| rs41267343 | 1:38,411,651 | A/G | — | benign |
| rs2526077318 | 1:38,411,926 | T/A | — | uncertain significance |
| rs375649873 | 1:38,411,929 | C/T | — | likely benign |
Showing 100 of 103 variants. Use the SNP search for the full list.
Gene information from NCBI Gene. Variant classifications from ClinVar.