MAP3K14

mitogen-activated protein kinase kinase kinase 14

Summary

This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq, Jul 2008]

Known Variants420 total

rsidPosition (GRCh37)AllelesClassClinVar
rs136542599717:43,342,015C/T—likely benign
rs76407784617:43,342,021C/T—likely benign
rs214375718717:43,342,024G/A—likely benign
rs75151742217:43,342,027A/G—likely benign
rs37532012517:43,342,050C/T—uncertain significance
rs78118492017:43,342,051G/A—likely benign
rs5603620117:43,342,064G/T—uncertain significance
rs156798460117:43,342,068C/T—uncertain significance
rs56907679817:43,342,078C/T—likely benign
rs14877967417:43,342,087G/A—likely benign
rs5575093817:43,342,093C/T—likely benign
rs77563019417:43,342,105C/T—likely benign
rs36779875617:43,342,118C/T—uncertain significance
rs76738238317:43,342,119G/A—uncertain significance
rs250895181517:43,342,120A/T—likely benign
rs127522465217:43,342,125G/A—uncertain significance
rs37165795717:43,342,132G/A—likely benign
rs204405998117:43,342,147G/A—likely benign
rs37427637417:43,342,153G/A—likely benign
rs116872398617:43,342,157G/C—uncertain significance
rs20181635317:43,342,513G/A—benign
rs37067872517:43,342,516C/T—likely benign
rs135131623217:43,342,519G/C—likely benign
rs77647930017:43,342,523C/T—likely benign
rs56841575117:43,342,524C/A—uncertain significance
rs78030600417:43,342,525C/T—uncertain significance
rs37438479717:43,342,541T/C—uncertain significance
rs77234979917:43,342,570C/T—uncertain significance
rs159823676117:43,342,581C/T—likely benign
rs250895488117:43,342,582C/T—uncertain significance
rs20068994717:43,342,594T/C—uncertain significance
rs204406744117:43,342,616T/C—uncertain significance
rs11313646717:43,342,639C/T—likely benign
rs20053633117:43,342,640G/A—likely benign
rs75241094717:43,342,647G/A—likely benign
rs37152768717:43,343,906T/C—uncertain significance
rs76678571317:43,343,925C/T—uncertain significance
rs75443785817:43,343,926G/A—likely benign
rs136504013517:43,343,927G/A—uncertain significance
rs75527122417:43,343,929G/C—likely benign
rs77947276017:43,343,933C/T—uncertain significance
rs204408508317:43,343,934G/A—uncertain significance
rs56175727717:43,343,939C/T—uncertain significance
rs77110860017:43,343,952T/C—uncertain significance
rs204408569517:43,343,953G/A—likely benign
rs57189862917:43,343,962G/A—likely benign
rs250896198717:43,343,963G/A—uncertain significance
rs37674637717:43,343,971A/G—likely benign
rs214376703917:43,343,980C/T—likely benign
rs36964686617:43,343,997G/A—uncertain significance
rs76375226717:43,344,000C/T—uncertain significance
rs127430356917:43,344,001G/A—likely benign
rs214376715817:43,344,012G/C—uncertain significance
rs75553503817:43,344,021G/T—likely benign
rs76562732917:43,344,022C/T—likely benign
rs144888356417:43,344,036C/A—uncertain significance
rs77813512217:43,344,045G/T—uncertain significance
rs101115027517:43,344,046G/T—uncertain significance
rs117659100517:43,344,055C/T—likely benign
rs3483678817:43,344,058C/T—likely benign
rs37009028817:43,344,062A/G—likely benign
rs76780459117:43,344,440G/A—likely benign
rs76459988617:43,344,441G/A—likely benign
rs143922420817:43,344,443G/A—likely benign
rs92119215917:43,344,451C/T—conflicting classifications of pathogenicity
rs54985846617:43,344,456C/T—uncertain significance
rs19099238317:43,344,474C/G—likely benign
rs74926684717:43,344,487C/G—uncertain significance
rs147209864817:43,344,492G/A—likely benign
rs55363290517:43,344,504C/T—likely benign
rs132482080217:43,344,505G/A—uncertain significance
rs86720397017:43,344,525C/T—likely benign
rs100278708817:43,344,555G/A—likely benign
rs105518442717:43,344,561T/C—likely benign
rs204409479717:43,344,563A/G—likely benign
rs101382947917:43,344,585A/T—likely benign
rs250896665517:43,344,753G/A—likely benign
rs37707036317:43,344,760C/T—benign
rs75195888817:43,344,761G/A—likely benign
rs125780828017:43,344,768C/T—uncertain significance
rs5690776317:43,344,769G/A—uncertain significance
rs78015933117:43,344,786C/T—likely benign
rs14841680017:43,344,787T/G—uncertain significance
rs119108339517:43,344,791G/A—likely benign
rs14242894717:43,344,798C/A—uncertain significance
rs1784684617:43,344,801C/T—likely benign
rs77744872917:43,344,806C/T—uncertain significance
rs74670605817:43,344,807G/A—likely benign
rs250896716317:43,344,808G/A—uncertain significance
rs5630255917:43,344,809T/C—conflicting classifications of pathogenicity
rs15129647117:43,344,810T/C—likely benign
rs204409907017:43,344,811G/C—uncertain significance
rs37152184717:43,344,817C/T—uncertain significance
rs77477922317:43,344,818G/A—uncertain significance
rs77340356717:43,344,833G/A—uncertain significance
rs137974508317:43,344,850G/C—uncertain significance
rs147845101517:43,344,851G/C—uncertain significance
rs204409989817:43,344,852C/T—likely benign
rs57183152917:43,344,862G/A—uncertain significance
rs135663235917:43,344,864C/T—likely benign

Showing 100 of 420 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.