MSL2
MSL complex subunit 2
Summary
Enables histone H2B ubiquitin ligase activity. Involved in DNA damage response and protein monoubiquitination. Located in nucleus. Part of MSL complex. Is active in chromatin. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants28 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2529543339 | 3:135,870,081 | C/G | — | uncertain significance |
| rs149034612 | 3:135,870,086 | A/G | — | uncertain significance |
| rs1939356475 | 3:135,870,098 | C/A | — | uncertain significance |
| rs1559954217 | 3:135,870,198 | T/G | — | uncertain significance |
| rs767323746 | 3:135,870,391 | C/T | — | uncertain significance |
| rs138243588 | 3:135,870,402 | G/C | — | uncertain significance |
| rs2529544826 | 3:135,870,426 | C/T | — | likely benign |
| rs374539493 | 3:135,870,495 | T/C | — | uncertain significance |
| rs975125568 | 3:135,870,500 | A/G | — | uncertain significance |
| rs761761323 | 3:135,870,529 | G/T | — | uncertain significance |
| rs765274711 | 3:135,870,537 | T/C | — | uncertain significance |
| rs1939377614 | 3:135,870,558 | G/A | — | uncertain significance |
| rs2529545718 | 3:135,870,614 | G/A | — | uncertain significance |
| rs139959327 | 3:135,870,731 | G/C | — | uncertain significance |
| rs1185198975 | 3:135,870,752 | T/A | — | uncertain significance |
| rs1559954925 | 3:135,870,764 | C/G | — | uncertain significance |
| rs146908606 | 3:135,870,984 | A/G | — | uncertain significance |
| rs138484914 | 3:135,871,065 | C/A | — | uncertain significance |
| rs2529547938 | 3:135,871,094 | G/A | — | uncertain significance |
| rs1191293140 | 3:135,871,130 | T/C | — | uncertain significance |
| rs2529548404 | 3:135,871,188 | C/A | — | pathogenic |
| rs149929074 | 3:135,871,560 | T/C | — | uncertain significance |
| rs113021516 | 3:135,874,294 | G/C | upstream gene variant | — |
| rs61791757 | 3:135,905,325 | G/T | — | — |
| rs13068210 | 3:135,905,546 | T/G | regulatory region variant | — |
| rs6779146 | 3:135,907,213 | T/A | — | — |
| rs745561575 | 3:135,913,883 | G/A | — | not provided |
| rs2529663010 | 3:135,913,889 | C/A | — | pathogenic |
Gene information from NCBI Gene. Variant classifications from ClinVar.