RAD51B
RAD51 paralog B
Summary
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. Rearrangements between this locus and high mobility group AT-hook 2 (HMGA2, GeneID 8091) have been observed in uterine leiomyomata. [provided by RefSeq, Mar 2016]
Known Variants175 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1009774288 | 14:68,290,267 | A/G | — | uncertain significance |
| rs34583846 | 14:68,290,285 | G/A | — | conflicting classifications of pathogenicity |
| rs764896402 | 14:68,290,344 | G/A | splice region variant | pathogenic |
| rs34355633 | 14:68,290,369 | T/C | — | benign |
| rs17783124 | 14:68,290,372 | T/G | — | benign |
| rs28604984 | 14:68,290,426 | T/C | — | benign |
| rs28623567 | 14:68,290,464 | G/A | — | benign |
| rs8006089 | 14:68,290,520 | T/G | — | benign |
| rs8011393 | 14:68,291,898 | C/T | — | benign |
| rs8011690 | 14:68,291,907 | G/A | — | benign |
| rs79415557 | 14:68,291,963 | T/A | — | benign |
| rs574178911 | 14:68,292,119 | T/C | — | likely benign |
| rs114131734 | 14:68,292,187 | T/C | — | benign |
| rs766897041 | 14:68,292,211 | A/G | — | uncertain significance |
| rs925254316 | 14:68,292,230 | G/A | — | uncertain significance |
| rs200355697 | 14:68,292,235 | C/T | — | uncertain significance |
| rs184815928 | 14:68,301,764 | G/T | — | benign |
| rs35183950 | 14:68,301,776 | C/T | — | benign |
| rs773742806 | 14:68,301,801 | A/G | — | uncertain significance |
| rs190059291 | 14:68,301,824 | G/A | — | conflicting classifications of pathogenicity |
| rs1484091620 | 14:68,301,893 | G/A | — | uncertain significance |
| rs181714884 | 14:68,301,921 | A/G | — | benign |
| rs17783160 | 14:68,302,127 | A/G | — | benign |
| rs961700 | 14:68,331,437 | G/A | — | benign |
| rs1474939 | 14:68,331,675 | A/T | — | benign |
| rs2503083175 | 14:68,331,762 | A/G | — | uncertain significance |
| rs150928231 | 14:68,331,765 | A/T | — | uncertain significance |
| rs200741476 | 14:68,331,840 | G/A | — | uncertain significance |
| rs1464701988 | 14:68,331,858 | T/C | — | uncertain significance |
| rs753393344 | 14:68,331,859 | A/G | — | conflicting classifications of pathogenicity |
| rs375203676 | 14:68,331,888 | T/C | — | likely benign |
| rs111710471 | 14:68,332,102 | C/A | — | benign |
| rs4902530 | 14:68,352,323 | A/G | — | benign |
| rs35080917 | 14:68,352,560 | G/A | — | benign |
| rs548280411 | 14:68,352,609 | G/A | — | likely benign |
| rs34094401 | 14:68,352,648 | T/G | — | benign |
| rs140423456 | 14:68,352,656 | A/C | — | benign |
| rs1460524254 | 14:68,352,662 | G/C | — | uncertain significance |
| rs28910275 | 14:68,352,672 | G/A | — | benign |
| rs199981178 | 14:68,352,674 | C/T | — | uncertain significance |
| rs8017007 | 14:68,352,905 | G/A | — | benign |
| rs371376587 | 14:68,353,744 | A/C | — | conflicting classifications of pathogenicity |
| rs28908168 | 14:68,353,784 | G/T | — | conflicting classifications of pathogenicity |
| rs2503164430 | 14:68,353,857 | G/A | — | uncertain significance |
| rs149154702 | 14:68,353,864 | G/A | — | likely benign |
| rs17104744 | 14:68,353,879 | G/A | — | benign |
| rs2503164814 | 14:68,353,892 | A/G | — | uncertain significance |
| rs34594234 | 14:68,353,893 | G/A | — | likely benign |
| rs33929366 | 14:68,353,913 | T/G | — | likely benign |
| rs34175580 | 14:68,353,939 | T/C | — | likely benign |
| rs4902531 | 14:68,354,152 | C/T | — | benign |
| rs4436722 | 14:68,375,615 | A/G | intron variant | — |
| rs2009191 | 14:68,377,707 | G/A | intron variant | — |
| rs72725141 | 14:68,405,244 | A/C | intron variant | — |
| rs7151917 | 14:68,413,769 | G/T | intron variant | — |
| rs17104800 | 14:68,420,779 | T/C | intron variant | — |
| rs113599586 | 14:68,435,810 | C/G | — | — |
| rs17783304 | 14:68,451,248 | A/T | — | — |
| rs11848769 | 14:68,463,352 | G/A | intron variant | — |
| rs72725151 | 14:68,466,362 | G/A | regulatory region variant | — |
| rs117405447 | 14:68,466,900 | T/C | — | likely benign |
| rs60415085 | 14:68,471,070 | A/T | intron variant | — |
| rs72725156 | 14:68,474,878 | T/C | intron variant | — |
| rs72725158 | 14:68,476,880 | T/C | intron variant | — |
| rs2093358 | 14:68,482,312 | T/C | intron variant | — |
| rs11158716 | 14:68,493,158 | G/A | intron variant | — |
| rs10129612 | 14:68,494,470 | C/G | — | — |
| rs72725168 | 14:68,500,954 | C/T | intron variant | — |
| rs72725170 | 14:68,501,714 | C/A | intron variant | — |
| rs10136868 | 14:68,514,238 | A/C | — | — |
| rs28470365 | 14:68,515,956 | A/G | intron variant | — |
| rs6573814 | 14:68,517,763 | T/A | — | — |
| rs8022206 | 14:68,520,906 | G/A | intron variant | — |
| rs184644645 | 14:68,549,210 | T/G | intron variant | — |
| rs74773190 | 14:68,554,769 | A/G | intron variant | — |
| rs186395099 | 14:68,557,839 | C/T | intron variant | — |
| rs144403523 | 14:68,559,336 | T/C | intron variant | — |
| rs2478777 | 14:68,629,267 | C/T | intron variant | — |
| rs1536457 | 14:68,651,341 | C/G | — | — |
| rs59333573 | 14:68,651,342 | C/G | — | — |
| rs2588808 | 14:68,660,181 | G/A | — | benign |
| rs2588809 | 14:68,660,428 | T/C | intron variant | benign |
| rs67007969 | 14:68,662,643 | C/T | — | — |
| rs2759405 | 14:68,669,308 | T/G | — | — |
| rs1274653 | 14:68,676,778 | G/A | intron variant | — |
| rs1296527 | 14:68,685,460 | T/C | intron variant | — |
| rs1314913 | 14:68,699,594 | C/T | regulatory region variant | — |
| rs1314921 | 14:68,715,181 | A/G | regulatory region variant | — |
| rs28498223 | 14:68,728,425 | C/T | intron variant | — |
| rs17105278 | 14:68,728,479 | T/C | intron variant | — |
| rs74435447 | 14:68,736,448 | C/T | intron variant | — |
| rs10131490 | 14:68,743,307 | A/T | — | — |
| rs3784099 | 14:68,749,927 | G/A | regulatory region variant | — |
| rs8008961 | 14:68,752,643 | C/T | regulatory region variant | — |
| rs911263 | 14:68,753,593 | C/T | regulatory region variant | — |
| rs2104047 | 14:68,754,417 | T/A | — | — |
| rs1885013 | 14:68,754,695 | G/A | intron variant | — |
| rs533348490 | 14:68,758,509 | T/C | — | likely benign |
| rs34518413 | 14:68,758,518 | T/C | — | benign |
| rs34573256 | 14:68,758,552 | T/C | — | benign |
Showing 100 of 175 variants. Use the SNP search for the full list.
Gene information from NCBI Gene. Variant classifications from ClinVar.