RGS17
regulator of G protein signaling 17
Summary
This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]
Known Variants31 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs556779833 | 6:153,332,804 | T/C | — | uncertain significance |
| rs945666234 | 6:153,345,402 | T/G | — | uncertain significance |
| rs151215161 | 6:153,345,582 | T/C | — | uncertain significance |
| rs137936923 | 6:153,345,624 | G/A | — | uncertain significance |
| rs761548542 | 6:153,347,647 | T/C | — | uncertain significance |
| rs1562314621 | 6:153,347,652 | C/G | — | uncertain significance |
| rs2295230 | 6:153,365,100 | A/T | synonymous variant | — |
| rs915161824 | 6:153,365,101 | G/A | — | uncertain significance |
| rs1489970805 | 6:153,365,117 | G/C | — | uncertain significance |
| rs1338071 | 6:153,365,834 | G/C | upstream gene variant | — |
| rs1338070 | 6:153,365,841 | G/T | upstream gene variant | — |
| rs9383643 | 6:153,374,482 | A/T | — | — |
| rs7750497 | 6:153,376,417 | C/T | downstream gene variant | — |
| rs9371277 | 6:153,377,217 | T/C | downstream gene variant | — |
| rs9383644 | 6:153,377,227 | A/T | — | — |
| rs6934238 | 6:153,378,061 | G/A | downstream gene variant | — |
| rs6935593 | 6:153,378,090 | C/G | — | — |
| rs6903981 | 6:153,379,664 | C/G | — | — |
| rs6913406 | 6:153,386,942 | G/A | intron variant | — |
| rs655370 | 6:153,413,460 | G/C | regulatory region variant | — |
| rs9371672 | 6:153,422,140 | C/A | — | — |
| rs9383649 | 6:153,428,102 | A/C | — | — |
| rs63739861 | 6:153,430,868 | A/C | intron variant | — |
| rs1281962 | 6:153,431,376 | G/C | intron variant | — |
| rs6932473 | 6:153,438,573 | A/T | intron variant | — |
| rs7758002 | 6:153,440,770 | G/C | — | — |
| rs1933488 | 6:153,441,079 | A/G | intron variant | — |
| rs9371676 | 6:153,445,965 | C/A | intron variant | — |
| rs6932847 | 6:153,448,307 | G/A | intron variant | — |
| rs112289739 | 6:153,451,065 | C/T | intron variant | — |
| rs572335259 | 6:153,451,172 | C/T | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.