SARM1
sterile alpha and TIR motif containing 1
Summary
Enables NAD+ nucleosidase activity; NAD+ nucleosidase activity, cyclic ADP-ribose generating; and identical protein binding activity. Involved in NAD catabolic process and response to axon injury. Is active in mitochondrion. [provided by Alliance of Genome Resources, Apr 2025]
Known Variants15 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1224579416 | 17:26,699,078 | G/C | — | uncertain significance |
| rs782269124 | 17:26,699,102 | G/C | — | uncertain significance |
| rs7212510 | 17:26,703,682 | T/A | upstream gene variant | — |
| rs144613221 | 17:26,712,165 | T/C | — | uncertain significance |
| rs967645 | 17:26,713,970 | C/G | — | — |
| rs6505077 | 17:26,715,948 | G/T | — | — |
| rs4794828 | 17:26,717,268 | G/T | — | — |
| rs6505079 | 17:26,718,177 | T/A | downstream gene variant | — |
| rs9913833 | 17:26,718,592 | C/T | downstream gene variant | — |
| rs4795435 | 17:26,720,564 | G/A | downstream gene variant | — |
| rs2239907 | 17:26,725,744 | T/G | — | benign |
| rs80338774 | 17:26,727,674 | G/C | missense variant | pathogenic |
| rs281875211 | 17:26,729,294 | C/T | missense variant | pathogenic |
| rs80338773 | 17:26,729,295 | G/A | missense variant | pathogenic |
| rs80338775 | 17:26,729,340 | C/T | coding sequence variant | pathogenic |
Gene information from NCBI Gene. Variant classifications from ClinVar.