SNAP91
synaptosome associated protein 91
Summary
Predicted to enable several functions, including clathrin adaptor activity; clathrin heavy chain binding activity; and phosphatidylinositol binding activity. Acts upstream of or within regulation of clathrin-dependent endocytosis. Predicted to be located in cytosol; postsynaptic density; and presynaptic membrane. Predicted to be active in several cellular components, including Schaffer collateral - CA1 synapse; cytoplasmic vesicle; and parallel fiber to Purkinje cell synapse. Predicted to be extrinsic component of presynaptic endocytic zone membrane. Biomarker of Alzheimer's disease. [provided by Alliance of Genome Resources, Apr 2025]
Known Variants67 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs556410761 | 6:84,265,943 | C/A | — | uncertain significance |
| rs774229973 | 6:84,265,945 | G/T | — | uncertain significance |
| rs202051437 | 6:84,269,839 | G/C | — | uncertain significance |
| rs200406307 | 6:84,269,897 | G/A | — | uncertain significance |
| rs12208676 | 6:84,270,601 | A/G | — | likely benign |
| rs187423527 | 6:84,270,613 | C/T | — | benign |
| rs2534662151 | 6:84,270,621 | C/T | — | uncertain significance |
| rs369361483 | 6:84,270,624 | C/T | — | uncertain significance |
| rs779933901 | 6:84,270,626 | G/A | — | uncertain significance |
| rs9350984 | 6:84,279,922 | G/T | intron variant | — |
| rs7752643 | 6:84,280,275 | C/T | — | — |
| rs2016358 | 6:84,283,733 | C/A | intron variant | — |
| rs1164130706 | 6:84,284,745 | G/A | — | uncertain significance |
| rs769258890 | 6:84,284,769 | G/A | — | uncertain significance |
| rs1294685099 | 6:84,284,776 | C/G | — | uncertain significance |
| rs761788942 | 6:84,284,807 | C/A | — | uncertain significance |
| rs780606231 | 6:84,285,758 | C/G | — | uncertain significance |
| rs201039955 | 6:84,291,956 | A/G | — | uncertain significance |
| rs61729902 | 6:84,291,977 | G/A | — | benign |
| rs6912747 | 6:84,292,032 | A/C | — | benign |
| rs2535840684 | 6:84,292,067 | C/G | — | uncertain significance |
| rs2535841056 | 6:84,292,073 | A/G | — | uncertain significance |
| rs777039637 | 6:84,300,947 | G/A | — | uncertain significance |
| rs199865724 | 6:84,300,969 | C/A | — | uncertain significance |
| rs755272450 | 6:84,300,971 | T/A | — | uncertain significance |
| rs778793061 | 6:84,300,996 | C/T | — | uncertain significance |
| rs375839747 | 6:84,301,011 | C/T | — | uncertain significance |
| rs776072694 | 6:84,302,207 | C/T | — | uncertain significance |
| rs1478316265 | 6:84,302,234 | G/A | — | uncertain significance |
| rs370500053 | 6:84,302,668 | A/G | — | uncertain significance |
| rs2536328320 | 6:84,302,928 | C/G | — | uncertain significance |
| rs377075958 | 6:84,303,242 | C/T | — | uncertain significance |
| rs200557175 | 6:84,303,295 | G/A | — | uncertain significance |
| rs755370506 | 6:84,303,361 | G/C | — | uncertain significance |
| rs753266739 | 6:84,303,388 | T/G | — | uncertain significance |
| rs62000381 | 6:84,303,447 | C/T | — | benign |
| rs375376910 | 6:84,303,448 | G/A | — | uncertain significance |
| rs201794377 | 6:84,304,096 | T/C | — | uncertain significance |
| rs770493529 | 6:84,304,144 | G/A | — | uncertain significance |
| rs375885217 | 6:84,311,008 | C/T | — | uncertain significance |
| rs758409288 | 6:84,311,049 | G/T | — | uncertain significance |
| rs186370272 | 6:84,311,055 | G/A | — | uncertain significance |
| rs16871625 | 6:84,311,160 | A/G | — | benign |
| rs140189735 | 6:84,311,324 | G/C | — | benign |
| rs540611975 | 6:84,315,430 | G/C | — | uncertain significance |
| rs752232664 | 6:84,317,459 | C/T | — | likely benign |
| rs7752421 | 6:84,317,533 | A/T | splice region variant | — |
| rs377581884 | 6:84,326,730 | T/G | — | uncertain significance |
| rs3798869 | 6:84,328,660 | G/A | intron variant | — |
| rs2537881985 | 6:84,337,860 | A/G | — | uncertain significance |
| rs12198480 | 6:84,342,600 | C/T | intron variant | — |
| rs217331 | 6:84,344,689 | G/C | intron variant | — |
| rs201947130 | 6:84,350,864 | C/A | — | uncertain significance |
| rs217310 | 6:84,364,565 | A/G | — | — |
| rs771692440 | 6:84,368,754 | T/C | — | uncertain significance |
| rs761031668 | 6:84,368,762 | T/C | — | uncertain significance |
| rs191843529 | 6:84,368,769 | T/C | — | benign |
| rs1197593226 | 6:84,368,804 | C/G | — | uncertain significance |
| rs367885907 | 6:84,371,254 | T/C | — | uncertain significance |
| rs762551616 | 6:84,371,318 | C/T | — | uncertain significance |
| rs12199980 | 6:84,372,889 | C/G | — | — |
| rs217304 | 6:84,372,935 | A/G | intron variant | — |
| rs1423110546 | 6:84,375,265 | T/C | — | uncertain significance |
| rs2539451243 | 6:84,375,286 | T/C | — | uncertain significance |
| rs217300 | 6:84,377,985 | G/A | intron variant | — |
| rs217289 | 6:84,401,807 | G/A | intron variant | — |
| rs61739350 | 6:84,417,629 | G/C | — | benign |
Gene information from NCBI Gene. Variant classifications from ClinVar.