TANC2

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2

Summary

Predicted to be a structural constituent of postsynaptic density. Predicted to be involved in dense core granule cytoskeletal transport; regulation of dendritic spine development; and regulation of dendritic spine morphogenesis. Predicted to act upstream of or within in utero embryonic development. Located in dendritic spine. Implicated in intellectual developmental disorder with autistic features and language delay, with or without seizures. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants376 total

rsidPosition (GRCh37)AllelesClassClinVar
rs7283949517:61,044,550A/Tcoding sequence variant—
rs7284314517:61,052,949T/Cdownstream gene variant—
rs7632633917:61,053,778A/Gdownstream gene variant—
rs158836617:61,076,428A/Gregulatory region variant—
rs203377389317:61,086,949T/G—uncertain significance
rs20184731417:61,086,973A/G—likely benign
rs6207662217:61,090,958A/C——
rs7284316617:61,098,296G/Tintron variant—
rs18641936917:61,127,138A/C—benign
rs19119473617:61,149,974A/Gintron variant—
rs250989926217:61,151,313G/A—uncertain significance
rs75011547117:61,151,321C/G—likely benign
rs14258283617:61,151,326G/A—likely benign
rs146878240017:61,151,330C/T—pathogenic
rs250989944917:61,151,333A/C—uncertain significance
rs214465741717:61,151,334G/C—uncertain significance
rs203648853317:61,151,337A/G—uncertain significance
rs78123553917:61,151,350C/T—likely benign
rs18336021017:61,151,354C/T—likely benign
rs76052039917:61,151,364G/A—uncertain significance
rs119408498117:61,176,539G/A—uncertain significance
rs77787311517:61,176,542T/C—uncertain significance
rs203752653017:61,176,554G/A—uncertain significance
rs37382215417:61,176,556G/A—uncertain significance
rs77514714417:61,176,559T/C—uncertain significance
rs251003262417:61,176,574G/A—uncertain significance
rs251003267217:61,176,576C/A—uncertain significance
rs37732893917:61,176,580G/A—likely benign
rs37046047517:61,176,585C/T—likely benign
rs37675706417:61,176,593T/C—likely benign
rs75402090617:61,176,598G/T—uncertain significance
rs55242063917:61,176,602G/C—uncertain significance
rs251003430517:61,176,717T/C—uncertain significance
rs1768274717:61,181,112G/Aintron variant—
rs7811982317:61,181,892T/G——
rs3453659417:61,188,396G/Aintron variant—
rs6207796617:61,228,262C/G——
rs204126823717:61,271,456C/G—uncertain significance
rs117449637317:61,271,465G/A—uncertain significance
rs37148201517:61,271,482A/G—likely benign
rs131919828017:61,271,487A/G—uncertain significance
rs251063255117:61,278,136C/G—likely pathogenic
rs18985360917:61,278,143C/T—likely benign
rs75519174017:61,278,150C/T—uncertain significance
rs129208277417:61,278,153A/G—uncertain significance
rs57668448117:61,278,188C/T—likely benign
rs251063376117:61,278,223C/T—uncertain significance
rs11769004017:61,278,229T/G—benign
rs204151107217:61,278,262A/G—uncertain significance
rs20152019717:61,278,267G/T—likely benign
rs251063451517:61,278,294G/A—uncertain significance
rs141955043917:61,278,319G/A—pathogenic
rs56198459617:61,315,172C/T—likely benign
rs214605282417:61,315,177A/G—uncertain significance
rs37760194017:61,315,207C/T—uncertain significance
rs14441251117:61,315,208G/A—uncertain significance
rs14742204117:61,315,209C/T—benign
rs145418323817:61,315,229G/A—uncertain significance
rs250939768017:61,315,237G/A—uncertain significance
rs122932852717:61,315,269G/A—pathogenic
rs246011117:61,315,272G/A—benign
rs214605382917:61,315,286G/T—uncertain significance
rs250939851717:61,315,290G/T—uncertain significance
rs75955889617:61,315,298G/C—uncertain significance
rs250939863717:61,315,302G/A—likely benign
rs54853991417:61,315,334C/G—uncertain significance
rs144861571217:61,315,341T/G—uncertain significance
rs131415000617:61,315,357G/A—uncertain significance
rs77999574317:61,315,359G/C—uncertain significance
rs204266998717:61,315,381T/C—uncertain significance
rs141579949017:61,315,386A/G—likely benign
rs132168109717:61,315,399A/G—uncertain significance
rs214605512217:61,315,409A/G—uncertain significance
rs76755658517:61,315,414A/C—uncertain significance
rs55841755417:61,315,425A/C—likely benign
rs138513341817:61,315,446T/G—likely benign
rs18891347917:61,330,502G/Tintron variant—
rs20006867517:61,345,103T/C—benign
rs57699019617:61,345,106C/T—uncertain significance
rs250960611017:61,345,114A/G—uncertain significance
rs250960615817:61,345,117T/A—uncertain significance
rs37085518017:61,345,154A/G—conflicting classifications of pathogenicity
rs20178866317:61,345,161T/C—likely benign
rs76488064317:61,345,165C/G—uncertain significance
rs76668163217:61,345,186A/G—uncertain significance
rs204357695017:61,345,200C/G—uncertain significance
rs75615130517:61,345,214G/A—uncertain significance
rs1260064117:61,389,844T/Cintron variant—
rs7284136817:61,391,114A/Tupstream gene variant—
rs37359924917:61,391,760C/T—uncertain significance
rs250988522717:61,391,811A/C—uncertain significance
rs130832295617:61,391,818C/T—uncertain significance
rs204524910617:61,391,857A/T—uncertain significance
rs139745625117:61,391,869C/T—uncertain significance
rs77043936717:61,391,933C/T—likely benign
rs204525414617:61,391,961G/A—uncertain significance
rs20097382417:61,391,969C/G—likely benign
rs204525458417:61,391,978T/A—uncertain significance
rs129521241617:61,392,000G/T—uncertain significance
rs132340726517:61,392,024C/T—uncertain significance

Showing 100 of 376 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.