TNFRSF14
TNF receptor superfamily member 14
Summary
This gene encodes a member of the TNF (tumor necrosis factor) receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Known Variants51 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2258734 | 1:2,483,961 | G/C | coding sequence variant | — |
| rs2227312 | 1:2,487,663 | C/G | — | — |
| rs565201292 | 1:2,487,767 | G/A | — | — |
| rs11573967 | 1:2,488,112 | T/C | — | benign |
| rs375570144 | 1:2,488,134 | C/T | — | uncertain significance |
| rs1213992714 | 1:2,488,140 | A/G | — | uncertain significance |
| rs752077330 | 1:2,489,165 | G/A | — | uncertain significance |
| rs897671259 | 1:2,489,227 | G/C | — | uncertain significance |
| rs753452393 | 1:2,489,267 | A/C | — | uncertain significance |
| rs11573975 | 1:2,490,452 | C/T | — | not provided |
| rs11573976 | 1:2,490,513 | C/G | — | not provided |
| rs587777980 | 1:2,490,531 | C/T | — | not provided |
| rs587777981 | 1:2,490,549 | C/T | — | not provided |
| rs565961218 | 1:2,490,608 | A/G | — | not provided |
| rs148507536 | 1:2,490,609 | T/C | — | not provided |
| rs535767072 | 1:2,490,786 | C/T | — | not provided |
| rs587777985 | 1:2,490,800 | G/T | — | not provided |
| rs587777986 | 1:2,490,861 | G/T | — | not provided |
| rs587777987 | 1:2,490,865 | T/A | — | not provided |
| rs2257763 | 1:2,490,898 | A/C | — | not provided |
| rs143920314 | 1:2,490,934 | C/A | — | not provided |
| rs2281852 | 1:2,490,942 | G/T | — | not provided |
| rs559512818 | 1:2,490,954 | C/T | — | not provided |
| rs587777992 | 1:2,491,013 | C/T | — | not provided |
| rs112070015 | 1:2,491,061 | G/A | — | not provided |
| rs143696469 | 1:2,491,071 | C/G | — | not provided |
| rs587777995 | 1:2,491,091 | G/A | — | not provided |
| rs2234160 | 1:2,491,164 | G/A | — | not provided |
| rs2234161 | 1:2,491,205 | C/T | — | not provided |
| rs771419721 | 1:2,491,273 | C/T | — | uncertain significance |
| rs1644280078 | 1:2,491,300 | G/C | — | uncertain significance |
| rs2234162 | 1:2,491,305 | C/T | — | not provided |
| rs2234163 | 1:2,491,306 | G/A | — | not provided |
| rs753742293 | 1:2,491,342 | G/A | — | likely benign |
| rs587778716 | 1:2,491,362 | C/T | — | not provided |
| rs35239228 | 1:2,491,365 | C/T | — | not provided |
| rs760189429 | 1:2,491,375 | G/A | — | uncertain significance |
| rs200772143 | 1:2,492,065 | A/G | — | uncertain significance |
| rs201844409 | 1:2,492,102 | C/T | — | uncertain significance |
| rs11573986 | 1:2,492,123 | G/A | — | not provided |
| rs778111546 | 1:2,492,134 | G/A | — | uncertain significance |
| rs587778000 | 1:2,492,972 | C/T | — | not provided |
| rs386352373 | 1:2,493,118 | C/G | — | uncertain significance |
| rs774759501 | 1:2,493,120 | G/T | — | uncertain significance |
| rs760122617 | 1:2,493,228 | T/C | — | uncertain significance |
| rs915586126 | 1:2,493,249 | C/T | — | uncertain significance |
| rs138489331 | 1:2,494,310 | T/C | — | uncertain significance |
| rs2234167 | 1:2,494,330 | G/A | — | not provided |
| rs371087831 | 1:2,494,645 | C/T | — | not provided |
| rs587778717 | 1:2,494,657 | C/T | — | not provided |
| rs779181014 | 1:2,494,665 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.