TNFRSF14

TNF receptor superfamily member 14

Summary

This gene encodes a member of the TNF (tumor necrosis factor) receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Known Variants51 total

rsidPosition (GRCh37)AllelesClassClinVar
rs22587341:2,483,961G/Ccoding sequence variant
rs22273121:2,487,663C/G
rs5652012921:2,487,767G/A
rs115739671:2,488,112T/Cbenign
rs3755701441:2,488,134C/Tuncertain significance
rs12139927141:2,488,140A/Guncertain significance
rs7520773301:2,489,165G/Auncertain significance
rs8976712591:2,489,227G/Cuncertain significance
rs7534523931:2,489,267A/Cuncertain significance
rs115739751:2,490,452C/Tnot provided
rs115739761:2,490,513C/Gnot provided
rs5877779801:2,490,531C/Tnot provided
rs5877779811:2,490,549C/Tnot provided
rs5659612181:2,490,608A/Gnot provided
rs1485075361:2,490,609T/Cnot provided
rs5357670721:2,490,786C/Tnot provided
rs5877779851:2,490,800G/Tnot provided
rs5877779861:2,490,861G/Tnot provided
rs5877779871:2,490,865T/Anot provided
rs22577631:2,490,898A/Cnot provided
rs1439203141:2,490,934C/Anot provided
rs22818521:2,490,942G/Tnot provided
rs5595128181:2,490,954C/Tnot provided
rs5877779921:2,491,013C/Tnot provided
rs1120700151:2,491,061G/Anot provided
rs1436964691:2,491,071C/Gnot provided
rs5877779951:2,491,091G/Anot provided
rs22341601:2,491,164G/Anot provided
rs22341611:2,491,205C/Tnot provided
rs7714197211:2,491,273C/Tuncertain significance
rs16442800781:2,491,300G/Cuncertain significance
rs22341621:2,491,305C/Tnot provided
rs22341631:2,491,306G/Anot provided
rs7537422931:2,491,342G/Alikely benign
rs5877787161:2,491,362C/Tnot provided
rs352392281:2,491,365C/Tnot provided
rs7601894291:2,491,375G/Auncertain significance
rs2007721431:2,492,065A/Guncertain significance
rs2018444091:2,492,102C/Tuncertain significance
rs115739861:2,492,123G/Anot provided
rs7781115461:2,492,134G/Auncertain significance
rs5877780001:2,492,972C/Tnot provided
rs3863523731:2,493,118C/Guncertain significance
rs7747595011:2,493,120G/Tuncertain significance
rs7601226171:2,493,228T/Cuncertain significance
rs9155861261:2,493,249C/Tuncertain significance
rs1384893311:2,494,310T/Cuncertain significance
rs22341671:2,494,330G/Anot provided
rs3710878311:2,494,645C/Tnot provided
rs5877787171:2,494,657C/Tnot provided
rs7791810141:2,494,665G/Auncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.