rs11530166
This variant is located in the MADD gene.
▶GWAS Catalog Trait Associations (10)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (10)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
free cholesterol to total lipids in medium HDL percentage
cholesterol in large HDL measurement
total lipids in large HDL
free cholesterol in large HDL measurement
free cholesterol to total lipids in very large HDL percentage
cholesterol in very large HDL measurement
total lipids in very large HDL measurement
phospholipids in very large HDL measurement
cholesteryl ester measurement
high density lipoprotein cholesterol measurement
About MADD
Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
View all MADD variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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