rs3757387

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GWAS Catalog Trait Associations (13)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

systemic lupus erythematosus

Yin X et al. “Meta-analysis of 208370 East Asians identifies 113 susceptibility loci for systemic lupus erythematosus.” Annals of the Rheumatic Diseases 80(5):632-640 (2021)
Allele T
OR 0.69
p 9.0e-79
N 208,370
Meta-analysisLarge GWAS
East Asian
Bentham J et al. “Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus.” Nature Genetics 47(12):1457-1464 (2015)
Allele T
OR 1.45
p 1.0e-48
N 14,267
Large GWAS
European

chromosome, telomeric region length

Burren OS et al. “Genetic architecture of telomere length in 462,666 UK Biobank whole-genome sequences.” Nature Genetics 56(9):1832-1840 (2024)
Allele T
OR 0.03
p 4.0e-39
N 438,351
Major Consortium StudyLarge GWAS
European

rheumatoid arthritis

Ishigaki K et al. “Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis.” Nature Genetics 54(11):1640-1651 (2022)
Allele C
OR 1.13
p 1.0e-26
N 276,020
Large GWAS
multi-ancestry
Saevarsdottir S et al. “Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset.” Annals of the Rheumatic Diseases 81(8):1085-1095 (2022)
Allele C
OR 0.93
p 2.0e-14
N 1,026,690
Large GWAS
European
Ha E et al. “Large-scale meta-analysis across East Asian and European populations updated genetic architecture and variant-driven biology of rheumatoid arthritis, identifying 11 novel susceptibility loci.” Annals of the Rheumatic Diseases 80(5):558-565 (2021)
Allele C
OR 0.88
p 2.0e-19
N 311,292
Meta-analysisLarge GWAS
multi-ancestry
Ishigaki K et al. “Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases.” Nature Genetics 52(7):669-679 (2020)
Allele C
OR 1.24
p 5.0e-9
N 212,453
Large GWAS
East Asian
Shigesi N et al. “The phenotypic and genetic association between endometriosis and immunological diseases.” Human Reproduction (oxford, England) 40(6):1195-1209 (2025)
Allele C
OR 0.04
p 5.0e-15
N 81,247
Large GWAS
European

Oral ulcer

Dudding T et al. “Genome wide analysis for mouth ulcers identifies associations at immune regulatory loci.” Nature Communications 10(1):1052 (2019)
Allele C
OR 1.05
p 3.0e-26
N 461,106
Large GWAS
European, NR

Sjogren syndrome

Lessard CJ et al. “Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome.” Nature Genetics 45(11):1284-92 (2013)
Allele C
OR 1.44
p 3.0e-19
N 2,370
Large GWAS
European

sclerosing cholangitis

Han Y et al. “Multitrait genome-wide analyses identify new susceptibility loci and candidate drugs to primary sclerosing cholangitis.” Nature Communications 14(1):1069 (2023)
Allele C
OR 0.08
p 2.0e-14
N 14,890
Large GWAS
European

eosinophil count

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.02
p 9.0e-12
N 447,598
Major Consortium StudyLarge GWAS
multi-ancestry

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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