rs4129585

This is a regulatory region variant variant in the TSNARE1 gene.

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GWAS Catalog Trait Associations (14)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

schizophrenia

Trubetskoy V et al. “Mapping genomic loci implicates genes and synaptic biology in schizophrenia.” Nature 604(7906):502-508 (2022)

Allele A

OR 1.07

p 9.0e-20

N 175,799

Large GWAS

multi-ancestry

Goes FS et al. “Genome-wide association study of schizophrenia in Ashkenazi Jews.” American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics 168(8):649-59 (2015)

Allele A

OR 1.08

p 8.0e-14

N 151,161

Large GWAS

Other

Ikeda M et al. “Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect.” Schizophrenia Bulletin 45(4):824-834 (2019)

Allele A

OR 1.08

p 4.0e-13

N 122,624

Large GWAS

multi-ancestry

“Biological insights from 108 schizophrenia-associated genetic loci.” Nature 511(7510):421-7 (2014)

Allele A

OR 1.09

p 2.0e-15

N 83,550

Large GWAS

multi-ancestry

Yao X et al. “Integrative analysis of genome-wide association studies identifies novel loci associated with neuropsychiatric disorders.” Translational Psychiatry 11(1):69 (2021)

Allele A

OR 0.08

p 6.0e-13

N 77,096

Large GWAS

European

Ripke S et al. “Genome-wide association analysis identifies 13 new risk loci for schizophrenia.” Nature Genetics 45(10):1150-9 (2013)

Allele A

OR 1.09

p 2.0e-10

N 32,143

Large GWAS

multi-ancestry

systolic blood pressure

Evangelou E et al. “Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.” Nature Genetics 50(10):1412-1425 (2018)

Allele A

OR 0.17

p 1.0e-12

N 757,601

Large GWAS

European

Koskeridis F et al. “Multi-trait association analysis reveals shared genetic loci between Alzheimer's disease and cardiovascular traits.” Nature Communications 15(1):9827 (2024)

Allele A

OR 0.01

p 3.0e-9

N 1,212,859

Large GWAS

European

Keaton JM et al. “Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits.” Nature Genetics 56(5):778-791 (2024)

Allele A

OR 0.16

p 1.0e-11

N 1,028,980

Large GWAS

multi-ancestry

Plotnikov D et al. “High Blood Pressure and Intraocular Pressure: A Mendelian Randomization Study.” Investigative Ophthalmology & Visual Science 63(6):29 (2022)

Allele A

OR 0.21

p 3.0e-9

N 526,001

Large GWAS

European

autism spectrum disorder, schizophrenia

“Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia.” Molecular Autism 8:21 (2017)

Allele A

OR 1.07

p 2.0e-12

N 17,968

Meta-analysisLarge GWAS

European

cognitive domain measurement

Schoeler T et al. “Combining cross-sectional and longitudinal genomic approaches to identify determinants of cognitive and physical decline.” Nature Communications 16(1):4524 (2025)

Allele A

OR 0.02

p 1.0e-11

N 181,587

Large GWAS

European

feeling nervous measurement

Nagel M et al. “Item-level analyses reveal genetic heterogeneity in neuroticism.” Nature Communications 9(1):905 (2018)

Allele A

OR 6.41

p 1.0e-10

N 373,121

Large GWAS

European

feeling tense measurement

Nagel M et al. “Item-level analyses reveal genetic heterogeneity in neuroticism.” Nature Communications 9(1):905 (2018)

Allele A

OR 6.15

p 8.0e-10

N 371,318

Large GWAS

European

diastolic blood pressure

Allele C

OR 0.09

p 8.0e-9

N 1,028,980

Large GWAS

multi-ancestry

anxiety measurement

Hill WD et al. “Genetic contributions to two special factors of neuroticism are associated with affluence, higher intelligence, better health, and longer life.” Molecular Psychiatry 25(11):3034-3052 (2020)

Allele A

OR 0.01

p 2.0e-8

N 270,059

Large GWAS

European

depressive symptom measurement

Baselmans BML et al. “Multivariate genome-wide analyses of the well-being spectrum.” Nature Genetics 51(3):445-451 (2019)

Allele C

OR 0.01

p 2.0e-8

N 1,067,913

Large GWAS

European

neuroticism measurement

Baselmans BML et al. “Multivariate genome-wide analyses of the well-being spectrum.” Nature Genetics 51(3):445-451 (2019)

Allele C

OR 0.01

p 2.0e-8

N 523,783

Large GWAS

European

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Research that mentions this SNP (1)

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Common variants in QPCT gene confer risk of schizophrenia in the Han Chinese population

MethodsRaja Amjad Waheed Khan et al.(2016)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

This paper presents CalPen, a web-based tool for calculating penetrance (disease likelihood given a mutation) in complex genetic disorders. The authors validated CalPen against published penetrance calculations for schizophrenia-associated copy number variants (CNVs) and single nucleotide polymorphisms (SNPs). They analyzed 15 CNVs in 39,059 schizophrenia patients and 55,084 controls (average penetrance 7%, ranging from ~1.4% for 15q11.2 deletions to ~20% for 22q11.21 CNVs) and 145 SNPs in 45,405 patients and 122,761 controls (average penetrance 0.7%, with rs1801028 showing the highest at 1.6%).

Traits studied:Schizophrenia

PubMed DOI Metascience Observatory

About TSNARE1

Predicted to enable SNAP receptor activity and SNARE binding activity. Predicted to be involved in intracellular protein transport; vesicle docking; and vesicle fusion. Predicted to be located in membrane. Predicted to be part of SNARE complex. Predicted to be active in synaptic vesicle. [provided by Alliance of Genome Resources, Jul 2025]

rs4129585

GWAS Catalog Trait Associations (14)

schizophrenia

systolic blood pressure

autism spectrum disorder, schizophrenia

cognitive domain measurement

feeling nervous measurement

feeling tense measurement

diastolic blood pressure

anxiety measurement

depressive symptom measurement

neuroticism measurement

Research that mentions this SNP (1)

About TSNARE1

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