rs663743
This variant is located in the CCDC88B gene.
▶GWAS Catalog Trait Associations (6)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (6)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
hypothyroidism
White SL et al. “Global multi-ancestry genome-wide analyses identify genes and biological pathways associated with thyroid cancer and benign thyroid diseases.” Nature Genetics 58(2):307-316 (2026)
Allele A
OR 0.04
p 1.0e-21
N 1,786,062
Large GWAS
European
Figuerêdo J et al. “Uncovering the shared genetic components of thyroid disorders and reproductive health.” European Journal of Endocrinology 191(2):211-222 (2024)
Allele A
OR 1.05
p 1.0e-8
N 691,986
Large GWAS
European
basal cell carcinoma
Choquet H et al. “Multi-ancestry genome-wide meta-analysis identifies novel basal cell carcinoma loci and shared genetic effects with squamous cell carcinoma.” Communications Biology 7(1):33 (2024)
Allele A
OR 1.07
p 1.0e-18
N 802,297
Meta-analysisLarge GWAS
European
Liyanage UE et al. “Combined analysis of keratinocyte cancers identifies novel genome-wide loci.” Human Molecular Genetics 28(18):3148-3160 (2019)
Allele A
OR 1.06
p 3.0e-10
N 651,138
Large GWAS
European
Adolphe C et al. “Genetic and functional interaction network analysis reveals global enrichment of regulatory T cell genes influencing basal cell carcinoma susceptibility.” Genome Medicine 13(1):19 (2021)
Allele A
OR 0.07
p 2.0e-9
N 392,871
Large GWAS
European
leprosy
Liu H et al. “Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy.” Nature Genetics 47(3):267-71 (2015)
Allele A
OR 1.24
p 9.0e-14
N 8,060
Large GWAS
East Asian
sclerosing cholangitis
Ji SG et al. “Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease.” Nature Genetics 49(2):269-273 (2017)
Allele G
OR 1.20
p 2.0e-13
N 14,890
Large GWAS
European
Han Y et al. “Multitrait genome-wide analyses identify new susceptibility loci and candidate drugs to primary sclerosing cholangitis.” Nature Communications 14(1):1069 (2023)
Allele G
OR 0.07
p 6.0e-9
N 14,890
Large GWAS
European
keratinocyte carcinoma
Liyanage UE et al. “Combined analysis of keratinocyte cancers identifies novel genome-wide loci.” Human Molecular Genetics 28(18):3148-3160 (2019)
Allele A
OR 1.05
p 2.0e-9
N 358,840
Large GWAS
European
sarcoidosis
Yuan S et al. “GWAS identifies genetic loci, lifestyle factors and circulating biomarkers that are risk factors for sarcoidosis.” Nature Communications 16(1):2481 (2025)
Allele A
OR 0.85
p 4.0e-21
N 1,374,560
Large GWAS
European
About CCDC88B
This gene encodes a member of the hook-related protein family. Members of this family are characterized by an N-terminal potential microtubule binding domain, a central coiled-coiled and a C-terminal Hook-related domain. The encoded protein may be involved in linking organelles to microtubules. [provided by RefSeq, Oct 2009]
View all CCDC88B variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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