rs7554511
This is a intron variant variant in the INAVA gene.
▶GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
inflammatory bowel disease
Jostins L et al. “Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.” Nature 491(7422):119-24 (2012)
Allele C
OR 1.16
p 1.0e-32
N 34,366
Large GWAS
European
ulcerative colitis
Liu JZ et al. “Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.” Nature Genetics 47(9):979-986 (2015)
Allele C
OR 1.18
p 7.0e-31
N 27,432
Large GWAS
multi-ancestry
Anderson CA et al. “Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.” Nature Genetics 43(3):246-52 (2011)
Allele C
OR 1.19
p 2.0e-13
N 26,405
Meta-analysisLarge GWAS
European
Crohn's disease
Liu JZ et al. “Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.” Nature Genetics 47(9):979-986 (2015)
Allele C
OR 1.16
p 2.0e-27
N 20,883
Large GWAS
multi-ancestry
About INAVA
Involved in several processes, including nucleotide-binding activity oligomerization domain containing 2 signaling pathway; positive regulation of cytokine production; and positive regulation of intracellular signal transduction. Located in cytoplasm and nuclear body. Implicated in inflammatory bowel disease 29. [provided by Alliance of Genome Resources, Jul 2025]
View all INAVA variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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