rs8005161
This is a regulatory region variant variant in the GPR65 gene.
▶GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
Crohn's disease
Franke A et al. “Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.” Nature Genetics 42(12):1118-25 (2010)
Allele T
OR 1.23
p 4.0e-18
N 21,389
Meta-analysisLarge GWAS
European
Liu JZ et al. “Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.” Nature Genetics 47(9):979-986 (2015)
Allele T
OR 1.17
p 9.0e-14
N 20,883
Large GWAS
multi-ancestry
inflammatory bowel disease
Jostins L et al. “Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.” Nature 491(7422):119-24 (2012)
Allele T
OR 1.15
p 2.0e-14
N 34,366
Large GWAS
European
ulcerative colitis
Liu JZ et al. “Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.” Nature Genetics 47(9):979-986 (2015)
Allele A
OR 1.14
p 3.0e-9
N 27,432
Large GWAS
multi-ancestry
About GPR65
Enables G protein-coupled receptor activity. Involved in several processes, including activation of GTPase activity; positive regulation of stress fiber assembly; and response to acidic pH. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
View all GPR65 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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