Trait
SNPs associated with total cholesterol in large LDL
51 genetic variants across 22 genes have been associated with total cholesterol in large LDL in published research. Key genes include ABCA6, ABCG8, APOA5.
Associated variants51 total
| rsid | Gene | Effect | Evidence |
|---|---|---|---|
| rs7412 | APOE | GWAS association (p=0.0e+00) | Large GWAS |
| rs11591147 | PCSK9 | GWAS association (p=5.0e-217) | Large GWAS |
| rs6511720 | LDLR | GWAS association (p=1.0e-213) | Large GWAS |
| rs646776 | CELSR2 | GWAS association (p=1.0e-206) | Large GWAS |
| rs563290 | — | GWAS association (p=6.0e-141) | Large GWAS |
| rs12916 | HMGCR | GWAS association (p=2.0e-86) | Large GWAS |
| rs174574 | FADS2 | GWAS association (p=3.0e-47) | Large GWAS |
| rs635634 | — | GWAS association (p=3.0e-46) | Large GWAS |
| rs181948526 | — | GWAS association (p=2.0e-43) | Large GWAS |
| rs4245791 | ABCG8 | GWAS association (p=5.0e-43) | Large GWAS |
| rs7177289 | — | GWAS association (p=7.0e-39) | Large GWAS |
| rs73001065 | — | GWAS association (p=8.0e-39) | Large GWAS |
| rs117113213 | — | GWAS association (p=4.0e-29) | Large GWAS |
| rs28601761 | — | GWAS association (p=7.0e-28) | Large GWAS |
| rs2287997 | — | GWAS association (p=8.0e-25) | Large GWAS |
| rs77542162 | ABCA6 | GWAS association (p=7.0e-24) | Large GWAS |
| rs484084 | — | GWAS association (p=3.0e-23) | Large GWAS |
| rs2618566 | — | GWAS association (p=4.0e-23) | Large GWAS |
| rs73066485 | — | GWAS association (p=2.0e-22) | Large GWAS |
| rs41279633 | — | GWAS association (p=2.0e-20) | Large GWAS |
| rs28929474 | SERPINA1 | GWAS association (p=2.0e-19) | Large GWAS |
| rs6882345 | — | GWAS association (p=7.0e-19) | Large GWAS |
| rs2740488 | — | GWAS association (p=2.0e-18) | Large GWAS |
| rs1168045 | — | GWAS association (p=4.0e-18) | Large GWAS |
| rs80254170 | — | GWAS association (p=1.0e-17) | Large GWAS |
| rs79598313 | — | GWAS association (p=2.0e-17) | Large GWAS |
| rs2126259 | LOC157273 | GWAS association (p=6.0e-17) | Large GWAS |
| rs7776156 | — | GWAS association (p=8.0e-17) | Large GWAS |
| rs6699113 | — | GWAS association (p=1.0e-15) | Large GWAS |
| rs4722551 | LOC105375199 | GWAS association (p=4.0e-15) | Large GWAS |
| rs76970536 | — | GWAS association (p=5.0e-15) | Large GWAS |
| rs3184504 | SH2B3 | GWAS association (p=1.0e-14) | Large GWAS |
| rs2244608 | HNF1A | GWAS association (p=5.0e-14) | Large GWAS |
| rs11601507 | — | GWAS association (p=6.0e-14) | Large GWAS |
| rs4794048 | — | GWAS association (p=3.0e-13) | Large GWAS |
| rs9391858 | — | GWAS association (p=6.0e-13) | Large GWAS |
| rs10832954 | SPTY2D1 | GWAS association (p=1.0e-12) | Large GWAS |
| rs36012880 | — | GWAS association (p=2.0e-12) | Large GWAS |
| rs1801689 | APOH | GWAS association (p=2.0e-12) | Large GWAS |
| rs13076933 | — | GWAS association (p=4.0e-12) | Large GWAS |
| rs11571725 | BRCA2 | GWAS association (p=6.0e-12) | Large GWAS |
| rs8111874 | — | GWAS association (p=2.0e-11) | Large GWAS |
| rs4876611 | TRPS1 | GWAS association (p=3.0e-11) | Large GWAS |
| rs72838098 | LOC107985940 | GWAS association (p=8.0e-11) | Large GWAS |
| rs3750329 | — | GWAS association (p=1.0e-10) | Large GWAS |
| rs9394283 | — | GWAS association (p=2.0e-10) | Large GWAS |
| rs4724102 | — | GWAS association (p=2.0e-10) | Large GWAS |
| rs61965607 | GPR180 | GWAS association (p=2.0e-10) | Large GWAS |
| rs964184 | APOA5 | GWAS association (p=3.0e-10) | Large GWAS |
| rs10020631 | TMPRSS11E | GWAS association (p=1.0e-09) | Large GWAS |
| rs77960347 | LIPG | GWAS association (p=1.0e-09) | Large GWAS |
Associations aggregated from the GWAS Catalog and curated literature. Informational only — not medical advice.