EXO1

exonuclease 1

Summary

This gene encodes a protein with 5' to 3' exonuclease activity as well as an RNase H activity. It is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in mismatch repair and recombination. Alternative splicing of this gene results in three transcript variants encoding two different isoforms. [provided by RefSeq, Jul 2008]

Known Variants84 total

rsidPosition (GRCh37)AllelesClassClinVar
rs37540931:242,010,116A/Gupstream gene variant
rs108029961:242,010,627C/Gregulatory region variant
rs17761801:242,011,344C/T
rs16355171:242,012,033G/Asplice region variant
rs17761771:242,012,149C/Tregulatory region variant
rs3723011451:242,013,800C/Auncertain significance
rs41498571:242,013,826C/Tbenign
rs14794554321:242,013,846T/Cuncertain significance
rs3687769461:242,013,896T/Clikely benign
rs41498631:242,015,591T/Cbenign
rs1996251321:242,015,649C/Tuncertain significance
rs41498641:242,015,658G/Abenign
rs41498651:242,015,709A/Gbenign
rs1435460231:242,016,703G/Auncertain significance
rs3678905941:242,016,717G/Alikely benign
rs7519772251:242,016,755C/Tuncertain significance
rs22369181:242,017,826C/Gintron variant
rs25267001:242,019,999C/T
rs7646637151:242,020,654G/Auncertain significance
rs7492316551:242,020,676C/Glikely benign
rs13715298251:242,020,677G/Auncertain significance
rs1439557741:242,020,699C/Tuncertain significance
rs24646486171:242,020,735A/Guncertain significance
rs1476773981:242,021,810A/Glikely benign
rs16611897161:242,021,812T/Cuncertain significance
rs16611898601:242,021,819G/Tuncertain significance
rs41499011:242,021,834A/Glikely benign
rs5602992461:242,021,896C/Tuncertain significance
rs7730147131:242,021,911G/Auncertain significance
rs24646616191:242,021,965G/Tuncertain significance
rs7705490191:242,021,985G/Cuncertain significance
rs11860551541:242,022,006C/Tuncertain significance
rs617509931:242,022,009G/Alikely benign
rs1493975341:242,023,882G/Aconflicting classifications of pathogenicity
rs41499091:242,023,898A/Gbenign
rs2007544921:242,023,901A/Guncertain significance
rs41499101:242,023,958A/Gbenign
rs5696953781:242,024,004G/Tlikely benign
rs7514056521:242,024,764C/Guncertain significance
rs24646938541:242,024,796A/Guncertain significance
rs16355091:242,028,027C/Tintron variant
rs7359431:242,030,151A/Gbenign
rs24647487091:242,030,205A/Guncertain significance
rs24647492691:242,030,240G/Cuncertain significance
rs727552951:242,034,263A/Gintron variant
rs1460987461:242,035,334C/Alikely benign
rs41499631:242,035,382C/Tbenign
rs13904259081:242,035,415A/Guncertain significance
rs13120781641:242,035,427G/Alikely benign
rs1496637381:242,035,430T/Clikely benign
rs41499641:242,035,433C/Abenign
rs41499651:242,035,438A/Gbenign
rs41499661:242,035,444G/Cbenign
rs41499671:242,035,574G/Cuncertain significance
rs16355011:242,040,775C/Tintron variant
rs10245254981:242,042,051G/Tuncertain significance
rs24648809051:242,042,119C/Guncertain significance
rs5686007901:242,042,131A/Guncertain significance
rs7650122241:242,042,133A/Guncertain significance
rs16625648761:242,042,196G/Tuncertain significance
rs1457895271:242,042,205C/Tuncertain significance
rs1438007051:242,042,206G/Alikely benign
rs7548860091:242,042,228G/Alikely benign
rs10478401:242,042,301G/Amissense variantbenign
rs1450182861:242,042,312A/Glikely benign
rs121227701:242,042,364A/Glikely benign
rs1838634131:242,042,399G/Alikely benign
rs41499781:242,042,437G/Alikely benign
rs7635238481:242,042,447C/Tlikely benign
rs617363311:242,042,454C/Tbenign
rs16625908201:242,042,461C/Guncertain significance
rs41499791:242,042,519C/Tlikely benign
rs17761481:242,042,545A/Gmissense variantbenign
rs7461139831:242,042,654A/Clikely benign
rs1877371601:242,045,263A/Guncertain significance
rs16354981:242,045,275C/Tmissense variantbenign
rs24649171441:242,045,296A/Guncertain significance
rs41500001:242,048,615G/Cconflicting classifications of pathogenicity
rs9217585511:242,048,659C/Tuncertain significance
rs93501:242,048,674C/Tmissense variantbenign
rs41500011:242,048,680G/Alikely benign
rs7709738521:242,048,819C/Tlikely benign
rs10012938431:242,052,844A/Cuncertain significance
rs8517971:242,053,042A/T

Gene information from NCBI Gene. Variant classifications from ClinVar.