KLB
klotho beta
Summary
Enables fibroblast growth factor binding activity and fibroblast growth factor receptor binding activity. Predicted to be involved in carbohydrate metabolic process. Predicted to act upstream of or within positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway and positive regulation of cell population proliferation. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants147 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs748905173 | 4:39,408,586 | C/T | — | uncertain significance |
| rs10003369 | 4:39,408,595 | C/A | — | benign |
| rs773653063 | 4:39,408,628 | A/G | — | uncertain significance |
| rs755268107 | 4:39,408,643 | G/A | — | uncertain significance |
| rs751424967 | 4:39,408,653 | T/C | — | likely benign |
| rs372258323 | 4:39,408,658 | T/C | — | uncertain significance |
| rs755711134 | 4:39,408,665 | C/T | — | likely benign |
| rs1367201904 | 4:39,408,677 | A/T | — | uncertain significance |
| rs748560537 | 4:39,408,681 | T/C | — | uncertain significance |
| rs1742744142 | 4:39,408,687 | A/G | — | uncertain significance |
| rs138789592 | 4:39,408,699 | C/T | — | likely benign |
| rs138076201 | 4:39,408,735 | G/A | — | likely benign |
| rs34905034 | 4:39,408,762 | C/G | — | benign |
| rs181580453 | 4:39,408,775 | C/T | — | uncertain significance |
| rs2109815022 | 4:39,408,802 | A/G | — | uncertain significance |
| rs764384920 | 4:39,408,912 | C/T | — | uncertain significance |
| rs56130063 | 4:39,408,989 | C/G | — | benign |
| rs1236802209 | 4:39,409,014 | T/C | — | uncertain significance |
| rs2475747300 | 4:39,409,017 | C/G | — | uncertain significance |
| rs1742754246 | 4:39,409,033 | G/T | — | uncertain significance |
| rs148640688 | 4:39,409,062 | A/G | — | benign |
| rs35733674 | 4:39,409,066 | T/C | — | conflicting classifications of pathogenicity |
| rs560220050 | 4:39,409,074 | G/A | — | uncertain significance |
| rs187055696 | 4:39,409,096 | G/A | — | conflicting classifications of pathogenicity |
| rs1252152398 | 4:39,409,105 | T/C | — | uncertain significance |
| rs146188956 | 4:39,409,109 | C/T | — | benign |
| rs765099477 | 4:39,409,193 | G/A | — | likely benign |
| rs1192494235 | 4:39,409,207 | C/T | — | uncertain significance |
| rs2109815387 | 4:39,409,216 | A/G | — | uncertain significance |
| rs1742759824 | 4:39,409,263 | C/T | — | uncertain significance |
| rs367707565 | 4:39,409,264 | G/A | — | uncertain significance |
| rs147372707 | 4:39,409,307 | T/C | — | likely benign |
| rs371147248 | 4:39,409,362 | G/T | — | uncertain significance |
| rs11940694 | 4:39,414,993 | A/G | regulatory region variant | — |
| rs35538052 | 4:39,418,965 | G/A | intron variant | — |
| rs183072761 | 4:39,420,307 | T/G | intron variant | — |
| rs13130794 | 4:39,422,242 | T/A | — | — |
| rs13125440 | 4:39,422,324 | A/G | intron variant | — |
| rs4975012 | 4:39,423,512 | G/A | intron variant | — |
| rs1542423 | 4:39,432,132 | C/T | intron variant | — |
| rs2926042 | 4:39,432,747 | G/A | intron variant | — |
| rs1253544246 | 4:39,435,812 | A/C | — | likely benign |
| rs761233375 | 4:39,435,838 | G/A | — | likely benign |
| rs201137531 | 4:39,435,876 | A/G | — | uncertain significance |
| rs1743421653 | 4:39,435,882 | A/T | — | uncertain significance |
| rs748070049 | 4:39,435,927 | A/T | — | uncertain significance |
| rs144494424 | 4:39,435,934 | G/A | — | benign |
| rs894886656 | 4:39,435,950 | A/G | — | uncertain significance |
| rs142460141 | 4:39,435,971 | A/G | — | uncertain significance |
| rs371635643 | 4:39,435,987 | G/C | — | uncertain significance |
| rs537328666 | 4:39,436,018 | C/T | — | likely benign |
| rs139498851 | 4:39,436,019 | G/A | — | benign |
| rs570589491 | 4:39,436,048 | G/A | — | likely benign |
| rs147899701 | 4:39,436,054 | C/T | — | likely benign |
| rs757467947 | 4:39,436,055 | G/A | — | uncertain significance |
| rs924776985 | 4:39,436,115 | G/A | — | uncertain significance |
| rs984923563 | 4:39,436,129 | A/T | — | likely benign |
| rs760929802 | 4:39,436,145 | C/A | — | uncertain significance |
| rs2109836041 | 4:39,436,152 | A/T | — | uncertain significance |
| rs751399162 | 4:39,436,178 | G/A | — | uncertain significance |
| rs116274139 | 4:39,436,201 | G/A | — | benign |
| rs369568090 | 4:39,436,275 | G/A | — | likely benign |
| rs777383398 | 4:39,439,367 | C/A | — | likely benign |
| rs1270847859 | 4:39,439,400 | G/C | — | uncertain significance |
| rs758719872 | 4:39,439,429 | C/A | — | likely benign |
| rs776640866 | 4:39,439,450 | T/C | — | likely benign |
| rs945390479 | 4:39,439,466 | A/G | — | uncertain significance |
| rs138571801 | 4:39,439,478 | C/T | — | uncertain significance |
| rs567666148 | 4:39,439,479 | G/A | — | uncertain significance |
| rs758019530 | 4:39,439,521 | G/A | — | conflicting classifications of pathogenicity |
| rs137923968 | 4:39,439,540 | A/C | — | uncertain significance |
| rs745937646 | 4:39,439,551 | C/T | — | uncertain significance |
| rs769288658 | 4:39,439,552 | G/T | — | likely benign |
| rs780447012 | 4:39,439,556 | G/C | — | uncertain significance |
| rs2475790821 | 4:39,439,622 | G/A | — | likely benign |
| rs4975016 | 4:39,439,719 | C/T | upstream gene variant | — |
| rs1261938126 | 4:39,447,969 | G/A | — | likely benign |
| rs776266026 | 4:39,448,000 | G/A | — | uncertain significance |
| rs373944576 | 4:39,448,047 | G/A | — | likely benign |
| rs2474964236 | 4:39,448,145 | C/G | — | uncertain significance |
| rs2474964242 | 4:39,448,150 | G/T | — | uncertain significance |
| rs2474964381 | 4:39,448,163 | T/C | — | uncertain significance |
| rs55755438 | 4:39,448,171 | A/G | — | benign |
| rs768164409 | 4:39,448,181 | T/G | — | uncertain significance |
| rs200760068 | 4:39,448,187 | C/T | — | uncertain significance |
| rs36100488 | 4:39,448,200 | G/A | — | benign |
| rs1743753070 | 4:39,448,247 | G/A | — | uncertain significance |
| rs140958291 | 4:39,448,260 | G/T | — | uncertain significance |
| rs144804057 | 4:39,448,261 | G/A | — | uncertain significance |
| rs147916209 | 4:39,448,302 | C/G | — | likely benign |
| rs141638078 | 4:39,448,345 | G/A | — | uncertain significance |
| rs765644764 | 4:39,448,363 | T/A | — | uncertain significance |
| rs188485566 | 4:39,448,419 | C/G | — | uncertain significance |
| rs746695765 | 4:39,448,450 | A/G | — | uncertain significance |
| rs372177724 | 4:39,448,459 | G/A | — | likely benign |
| rs144449983 | 4:39,448,474 | G/A | — | conflicting classifications of pathogenicity |
| rs1743758968 | 4:39,448,475 | G/A | — | uncertain significance |
| rs17618244 | 4:39,448,529 | G/A | missense variant | benign |
| rs746501741 | 4:39,448,540 | C/G | — | uncertain significance |
| rs7685429 | 4:39,448,542 | G/C | — | benign |
Showing 100 of 147 variants. Use the SNP search for the full list.
Gene information from NCBI Gene. Variant classifications from ClinVar.