ZMIZ1

zinc finger MIZ-type containing 1

Summary

This gene encodes a member of the PIAS (protein inhibitor of activated STAT) family of proteins. The encoded protein regulates the activity of various transcription factors, including the androgen receptor, Smad3/4, and p53. The encoded protein may also play a role in sumoylation. A translocation between this locus on chromosome 10 and the protein tyrosine kinase ABL1 locus on chromosome 9 has been associated with acute lymphoblastic leukemia. [provided by RefSeq, Mar 2010]

Known Variants529 total

rsidPosition (GRCh37)AllelesClassClinVar
rs498002010:80,827,632G/Ccoding sequence variant—
rs1226363610:80,833,662G/Aregulatory region variant—
rs70401010:80,841,148T/A——
rs125000910:80,845,411G/C——
rs125000310:80,846,814C/Tintron variant—
rs248669510:80,871,063G/Aintron variant—
rs118039153710:80,899,396G/A—uncertain significance
rs1082472210:80,905,542C/Tregulatory region variant—
rs77993310:80,918,517G/Aregulatory region variant—
rs7281626310:80,925,325C/Aintron variant—
rs791644110:80,925,577G/Cintron variant—
rs70399210:80,927,651C/T——
rs1159794710:80,928,321C/Tintron variant—
rs78015110:80,931,481G/Aregulatory region variant—
rs70398710:80,939,219G/T——
rs70398510:80,940,740A/Tregulatory region variant—
rs391593210:80,941,936G/Cregulatory region variant—
rs1257175110:80,942,631A/Gintron variant—
rs70398110:80,942,855G/Cintron variant—
rs70398010:80,943,841G/Aregulatory region variant—
rs70397710:80,944,230T/G—benign
rs7414232910:80,949,988C/Tregulatory region variant—
rs70397010:80,953,136A/Cintron variant—
rs70396510:80,955,067C/Tregulatory region variant—
rs1012826410:80,959,973T/Cregulatory region variant—
rs280236910:80,960,828C/Aintron variant—
rs19081715910:80,961,383G/A—benign
rs75593981710:80,961,411A/T—uncertain significance
rs249332525710:80,961,424A/G—uncertain significance
rs249332530110:80,961,426G/A—uncertain significance
rs20163190410:80,961,440C/T—benign
rs75548835010:80,961,460G/C—likely benign
rs184841424210:80,968,107T/G—likely benign
rs249337028010:80,968,111A/G—uncertain significance
rs249337031610:80,968,117C/T—likely benign
rs55962189410:80,968,125C/T—likely benign
rs249337049410:80,968,135C/G—uncertain significance
rs91546389310:80,968,137G/T—likely benign
rs75314143510:80,968,138C/T—likely benign
rs75670332510:80,968,149C/T—likely benign
rs76452492310:80,968,150G/A—uncertain significance
rs14298692110:80,968,167C/T—benign
rs75764929610:80,968,169A/G—uncertain significance
rs19970661610:80,968,172G/A—likely benign
rs74690391810:80,968,187G/A—uncertain significance
rs15068097510:80,968,191G/A—likely benign
rs249337112510:80,968,201T/G—uncertain significance
rs57420627210:80,968,205C/T—uncertain significance
rs76976346810:80,968,209G/A—benign
rs77468785210:80,968,219C/G—likely benign
rs37225418210:80,968,225C/T—likely benign
rs37516532810:80,968,226G/A—benign
rs249341020310:80,975,920T/A—uncertain significance
rs74905197510:80,975,940G/A—likely benign
rs249341053910:80,975,957T/C—uncertain significance
rs184872323010:80,975,985G/A—likely benign
rs103922058810:80,976,004C/T—pathogenic
rs75073957510:80,976,009C/T—likely benign
rs36841641410:80,976,021G/A—likely benign
rs155481791010:80,976,023A/G—likely pathogenic
rs18842818010:80,976,030C/T—uncertain significance
rs75605921110:80,976,031G/A—conflicting classifications of pathogenicity
rs20130497810:80,976,041C/T—likely benign
rs7610931110:81,003,146A/Gregulatory region variant—
rs213290901410:81,015,148A/G—uncertain significance
rs1159357610:81,015,896C/Tintron variant—
rs125054610:81,032,532A/T——
rs125054410:81,032,885G/C——
rs125054210:81,034,670G/Aregulatory region variant—
rs125054110:81,034,913G/Cregulatory region variant—
rs125054010:81,036,007A/Gintron variant—
rs7752486910:81,036,921T/C—benign
rs122365080110:81,036,934G/A—likely benign
rs77131738410:81,036,939C/T—likely benign
rs18362707310:81,036,948C/T—likely benign
rs75998435910:81,036,951C/T—likely benign
rs76355190810:81,036,966C/T—likely benign
rs75380931410:81,036,967G/A—uncertain significance
rs75719940410:81,036,969C/T—likely benign
rs76523056010:81,036,970C/G—uncertain significance
rs141436051810:81,036,971G/A—uncertain significance
rs249374127410:81,036,985C/T—likely pathogenic
rs14983632010:81,036,987A/G—likely benign
rs75821781410:81,037,001G/A—conflicting classifications of pathogenicity
rs37389597910:81,037,008C/T—likely benign
rs75618259810:81,037,009G/A—conflicting classifications of pathogenicity
rs121301646810:81,037,036C/T—uncertain significance
rs77261202910:81,037,042C/G—conflicting classifications of pathogenicity
rs147789177710:81,037,046G/A—likely benign
rs139535409710:81,037,060A/G—likely benign
rs185236071910:81,037,066C/T—uncertain significance
rs185236083410:81,037,067C/A—uncertain significance
rs185236181210:81,037,075T/C—uncertain significance
rs14684756510:81,037,077G/A—likely benign
rs11356261910:81,037,082G/A—likely benign
rs11386322310:81,037,083G/A—likely pathogenic
rs18729407710:81,037,094G/C—benign
rs125056910:81,045,207T/Cregulatory region variant—
rs19092887110:81,045,238A/T—benign
rs57052077410:81,045,286C/T—likely benign

Showing 100 of 529 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.