BAG6
BAG cochaperone 6
Summary
This gene was first characterized as part of a cluster of genes located within the human major histocompatibility complex class III region. This gene encodes a nuclear protein that is cleaved by caspase 3 and is implicated in the control of apoptosis. In addition, the protein forms a complex with E1A binding protein p300 and is required for the acetylation of p53 in response to DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Known Variants62 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2077492 | 6:31,606,392 | G/A | downstream gene variant | — |
| rs200090506 | 6:31,606,939 | T/C | — | uncertain significance |
| rs367689596 | 6:31,606,949 | G/A | — | uncertain significance |
| rs1281308977 | 6:31,606,982 | G/A | — | uncertain significance |
| rs374964997 | 6:31,606,988 | G/C | — | uncertain significance |
| rs750332 | 6:31,607,050 | C/T | downstream gene variant | — |
| rs753778566 | 6:31,607,323 | C/T | — | uncertain significance |
| rs781712151 | 6:31,607,350 | C/T | — | uncertain significance |
| rs767561330 | 6:31,607,368 | G/A | — | uncertain significance |
| rs145840472 | 6:31,607,375 | G/A | — | uncertain significance |
| rs148136430 | 6:31,607,421 | C/T | — | benign |
| rs62395804 | 6:31,607,952 | G/A | downstream gene variant | — |
| rs1427453669 | 6:31,607,996 | T/C | — | uncertain significance |
| rs371792038 | 6:31,608,221 | G/A | — | uncertain significance |
| rs903697326 | 6:31,608,456 | A/T | — | uncertain significance |
| rs891918045 | 6:31,608,702 | C/T | — | uncertain significance |
| rs747689534 | 6:31,608,711 | C/T | — | uncertain significance |
| rs904232684 | 6:31,608,885 | C/T | — | uncertain significance |
| rs763111364 | 6:31,608,944 | G/C | — | likely benign |
| rs142878083 | 6:31,609,116 | C/T | — | likely benign |
| rs1356499305 | 6:31,609,554 | C/T | — | uncertain significance |
| rs765679103 | 6:31,609,611 | C/A | — | uncertain significance |
| rs2534859628 | 6:31,610,064 | G/T | — | likely benign |
| rs1339448999 | 6:31,610,140 | G/C | — | uncertain significance |
| rs1344493005 | 6:31,610,144 | G/A | — | uncertain significance |
| rs753529121 | 6:31,610,865 | G/A | — | uncertain significance |
| rs181930340 | 6:31,611,425 | C/G | — | — |
| rs146784903 | 6:31,611,680 | C/T | — | likely benign |
| rs2077102 | 6:31,611,840 | C/A | intron variant | — |
| rs116953913 | 6:31,612,272 | C/T | intron variant | — |
| rs1787412741 | 6:31,612,725 | T/C | — | uncertain significance |
| rs35843778 | 6:31,612,787 | C/T | — | benign |
| rs544232605 | 6:31,612,929 | G/T | — | uncertain significance |
| rs771305744 | 6:31,612,933 | G/A | — | uncertain significance |
| rs138038562 | 6:31,613,237 | T/C | — | uncertain significance |
| rs377452760 | 6:31,613,282 | T/C | — | uncertain significance |
| rs555713768 | 6:31,613,379 | G/A | — | likely benign |
| rs2844464 | 6:31,613,991 | A/C | — | — |
| rs755211586 | 6:31,614,253 | C/T | — | uncertain significance |
| rs151105635 | 6:31,615,374 | G/A | — | uncertain significance |
| rs141096047 | 6:31,615,386 | G/A | — | uncertain significance |
| rs370794270 | 6:31,615,422 | G/A | — | uncertain significance |
| rs866143115 | 6:31,615,432 | G/A | — | uncertain significance |
| rs10484558 | 6:31,615,514 | T/C | synonymous variant | — |
| rs762045396 | 6:31,615,569 | G/A | — | uncertain significance |
| rs805303 | 6:31,616,366 | G/A | upstream gene variant | — |
| rs148812517 | 6:31,616,491 | A/G | — | uncertain significance |
| rs2536092605 | 6:31,616,735 | C/T | — | uncertain significance |
| rs762152993 | 6:31,617,056 | G/T | — | uncertain significance |
| rs780413093 | 6:31,617,064 | C/A | — | uncertain significance |
| rs115963254 | 6:31,617,150 | G/A | — | benign |
| rs2536194079 | 6:31,617,359 | T/C | — | uncertain significance |
| rs2536201375 | 6:31,617,403 | A/G | — | uncertain significance |
| rs73728965 | 6:31,619,535 | C/T | — | benign |
| rs3117583 | 6:31,619,576 | A/G | regulatory region variant | — |
| rs2736201 | 6:31,620,134 | A/C | — | — |
| rs571850429 | 6:31,620,138 | C/A | — | — |
| rs3117582 | 6:31,620,520 | T/G | regulatory region variant | — |
| rs12525463 | 6:31,621,784 | G/A | downstream gene variant | — |
| rs1266078 | 6:31,622,043 | T/A | — | — |
| rs9267528 | 6:31,622,141 | C/T | downstream gene variant | — |
| rs74890500 | 6:31,622,348 | G/A | downstream gene variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.