TNFSF15
TNF superfamily member 15
Summary
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Known Variants27 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs4574921 | 9:117,538,334 | C/T | — | uncertain risk allele |
| rs10114470 | 9:117,547,772 | T/C | 3 prime UTR variant | uncertain risk allele |
| rs7853287 | 9:117,549,327 | G/A | 3 prime UTR variant | — |
| rs3810936 | 9:117,552,885 | T/C | synonymous variant | — |
| rs762427267 | 9:117,552,925 | T/C | — | uncertain significance |
| rs149700202 | 9:117,552,943 | G/A | — | uncertain significance |
| rs368084272 | 9:117,553,057 | G/A | — | uncertain significance |
| rs1403226813 | 9:117,553,094 | T/C | — | uncertain significance |
| rs746621637 | 9:117,553,147 | A/T | — | uncertain significance |
| rs16931745 | 9:117,553,158 | A/T | — | benign |
| rs4246905 | 9:117,553,249 | T/A | — | — |
| rs147641716 | 9:117,554,712 | T/G | — | benign |
| rs772513068 | 9:117,554,715 | G/A | — | likely benign |
| rs780453763 | 9:117,555,842 | T/C | — | uncertain significance |
| rs6478108 | 9:117,558,703 | C/G | — | confers sensitivity |
| rs4366152 | 9:117,564,875 | T/C | intron variant | — |
| rs4263839 | 9:117,566,440 | A/G | regulatory region variant | — |
| rs4979462 | 9:117,567,013 | C/T | regulatory region variant | — |
| rs554137268 | 9:117,568,115 | G/A | — | uncertain significance |
| rs1392705533 | 9:117,568,144 | A/T | — | uncertain significance |
| rs1587903724 | 9:117,568,173 | G/A | — | likely benign |
| rs201981566 | 9:117,568,192 | C/T | — | uncertain significance |
| rs750605115 | 9:117,568,211 | C/A | — | uncertain significance |
| rs150191342 | 9:117,568,219 | C/T | — | benign |
| rs146813484 | 9:117,568,230 | G/T | — | uncertain significance |
| rs6478109 | 9:117,568,766 | A/G | regulatory region variant | — |
| rs7848647 | 9:117,569,046 | T/C | upstream gene variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.