NCOA2
nuclear receptor coactivator 2
Summary
The protein encoded by this gene functions as a transcriptional coactivator for nuclear hormone receptors, including steroid, thyroid, retinoid, and vitamin D receptors. The encoded protein acts as an intermediary factor for the ligand-dependent activity of these nuclear receptors, which regulate their target genes upon binding of cognate response elements. This gene has been found to be involved in translocations that result in fusions with other genes in various cancers, including the lysine acetyltransferase 6A (KAT6A) gene in acute myeloid leukemia, the ETS variant 6 (ETV6) gene in acute lymphoblastic leukemia, and the hes related family bHLH transcription factor with YRPW motif 1 (HEY1) gene in mesenchymal chondrosarcoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Known Variants101 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs61754973 | 8:71,033,566 | T/C | — | uncertain significance |
| rs780386461 | 8:71,033,622 | T/C | — | uncertain significance |
| rs769852666 | 8:71,036,133 | T/C | — | uncertain significance |
| rs1449094046 | 8:71,036,213 | C/A | — | uncertain significance |
| rs1262405635 | 8:71,036,931 | G/A | — | likely benign |
| rs749256695 | 8:71,037,059 | T/A | — | uncertain significance |
| rs200990162 | 8:71,039,090 | G/T | — | uncertain significance |
| rs370731230 | 8:71,039,138 | T/C | — | uncertain significance |
| rs761066825 | 8:71,039,182 | C/T | — | uncertain significance |
| rs753507017 | 8:71,039,221 | C/T | — | uncertain significance |
| rs2228592 | 8:71,040,683 | A/G | — | benign |
| rs375387776 | 8:71,040,945 | C/A | — | uncertain significance |
| rs757059586 | 8:71,041,034 | C/T | — | uncertain significance |
| rs752663152 | 8:71,041,145 | A/G | — | uncertain significance |
| rs115177449 | 8:71,041,146 | C/T | — | likely benign |
| rs375519556 | 8:71,041,151 | G/A | — | uncertain significance |
| rs779379781 | 8:71,041,170 | T/C | — | uncertain significance |
| rs1292841322 | 8:71,044,134 | G/A | — | uncertain significance |
| rs201261778 | 8:71,044,232 | G/A | — | uncertain significance |
| rs747862440 | 8:71,044,234 | C/G | — | uncertain significance |
| rs369246166 | 8:71,050,492 | G/A | — | uncertain significance |
| rs371139839 | 8:71,050,530 | C/G | — | uncertain significance |
| rs375662735 | 8:71,050,548 | C/T | — | uncertain significance |
| rs377408628 | 8:71,050,557 | T/A | — | uncertain significance |
| rs747409806 | 8:71,053,445 | G/A | — | likely benign |
| rs762541626 | 8:71,053,488 | T/C | — | uncertain significance |
| rs746009713 | 8:71,053,509 | T/C | — | uncertain significance |
| rs199857488 | 8:71,053,571 | G/A | — | uncertain significance |
| rs374615842 | 8:71,056,979 | G/C | — | uncertain significance |
| rs1810830460 | 8:71,056,993 | G/A | — | uncertain significance |
| rs373051604 | 8:71,060,577 | G/A | — | uncertain significance |
| rs149570843 | 8:71,060,641 | G/T | — | uncertain significance |
| rs1192427644 | 8:71,068,273 | G/A | — | uncertain significance |
| rs1812265480 | 8:71,068,414 | G/T | — | uncertain significance |
| rs369778520 | 8:71,068,415 | T/C | — | uncertain significance |
| rs1239690862 | 8:71,068,448 | C/T | — | uncertain significance |
| rs61754971 | 8:71,068,582 | G/C | — | uncertain significance |
| rs762541690 | 8:71,068,705 | A/G | — | uncertain significance |
| rs1812303531 | 8:71,068,709 | T/C | — | uncertain significance |
| rs368861974 | 8:71,068,801 | G/C | — | uncertain significance |
| rs745782507 | 8:71,068,811 | T/C | — | uncertain significance |
| rs777620838 | 8:71,068,882 | G/C | — | uncertain significance |
| rs2537864945 | 8:71,068,897 | T/C | — | uncertain significance |
| rs370956499 | 8:71,068,898 | T/G | — | uncertain significance |
| rs61753706 | 8:71,068,947 | C/T | — | likely benign |
| rs2537875127 | 8:71,069,075 | G/A | — | uncertain significance |
| rs764987424 | 8:71,069,103 | G/T | — | uncertain significance |
| rs1447723896 | 8:71,069,116 | C/G | — | uncertain significance |
| rs2537877652 | 8:71,069,122 | C/T | — | uncertain significance |
| rs2537882516 | 8:71,069,202 | T/A | — | uncertain significance |
| rs746008209 | 8:71,069,219 | T/C | — | uncertain significance |
| rs2537886401 | 8:71,069,270 | A/G | — | uncertain significance |
| rs369146284 | 8:71,069,286 | C/T | — | uncertain significance |
| rs2537888183 | 8:71,069,290 | G/A | — | uncertain significance |
| rs748565262 | 8:71,069,380 | G/A | — | uncertain significance |
| rs748237390 | 8:71,069,449 | G/A | — | uncertain significance |
| rs373075061 | 8:71,069,456 | T/C | — | uncertain significance |
| rs746206192 | 8:71,071,827 | A/G | — | uncertain significance |
| rs41391448 | 8:71,073,700 | T/C | intron variant | — |
| rs1585905814 | 8:71,075,076 | A/C | — | likely benign |
| rs267601983 | 8:71,075,715 | G/C | — | uncertain significance |
| rs199861060 | 8:71,078,874 | T/G | — | uncertain significance |
| rs2538241251 | 8:71,078,882 | T/C | — | uncertain significance |
| rs374076743 | 8:71,078,921 | C/T | — | uncertain significance |
| rs2538244120 | 8:71,078,944 | T/C | — | uncertain significance |
| rs2538359183 | 8:71,082,446 | T/C | — | uncertain significance |
| rs1563562961 | 8:71,082,574 | T/C | — | uncertain significance |
| rs57994514 | 8:71,102,751 | C/A | intron variant | — |
| rs576050421 | 8:71,110,647 | T/G | — | — |
| rs62530460 | 8:71,114,795 | G/A | intron variant | — |
| rs4737301 | 8:71,120,213 | G/A | intron variant | — |
| rs4737302 | 8:71,120,277 | A/T | — | — |
| rs1443622341 | 8:71,126,259 | T/C | — | uncertain significance |
| rs201894717 | 8:71,126,297 | T/C | — | uncertain significance |
| rs61753707 | 8:71,128,963 | T/C | — | benign |
| rs72663955 | 8:71,139,330 | T/G | intron variant | — |
| rs2977986 | 8:71,143,556 | A/T | — | — |
| rs75349541 | 8:71,152,803 | C/A | — | — |
| rs2977976 | 8:71,162,117 | G/A | intron variant | — |
| rs2926705 | 8:71,166,017 | A/G | — | — |
| rs2926702 | 8:71,167,994 | C/T | intron variant | — |
| rs2926701 | 8:71,170,604 | C/T | intron variant | — |
| rs2977980 | 8:71,171,858 | T/C | — | — |
| rs2926700 | 8:71,175,228 | C/T | intron variant | — |
| rs150377334 | 8:71,177,444 | C/A | intron variant | — |
| rs16936870 | 8:71,189,342 | T/A | downstream gene variant | — |
| rs1903343 | 8:71,231,706 | C/G | — | — |
| rs7815798 | 8:71,232,887 | C/A | — | — |
| rs4410938 | 8:71,251,084 | C/T | intron variant | — |
| rs10504473 | 8:71,260,332 | A/G | — | — |
| rs7841047 | 8:71,265,978 | G/A | upstream gene variant | — |
| rs74783055 | 8:71,277,238 | T/C | intron variant | — |
| rs558111321 | 8:71,290,357 | G/A | — | — |
| rs71517442 | 8:71,315,917 | G/A | regulatory region variant | — |
| rs6991199 | 8:71,316,597 | G/A | regulatory region variant | — |
| rs11776606 | 8:71,320,297 | C/A | upstream gene variant | — |
| rs34038289 | 8:71,333,037 | G/A | downstream gene variant | — |
| rs74993692 | 8:71,334,286 | C/T | downstream gene variant | — |
| rs11775808 | 8:71,334,847 | T/C | downstream gene variant | — |
| rs67436663 | 8:71,347,626 | G/T | — | — |
Showing 100 of 101 variants. Use the SNP search for the full list.
Gene information from NCBI Gene. Variant classifications from ClinVar.